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How to get fromLa Crosse to Greenvilleby plane, train, bus, car, taxi, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 7 ways to get from La Crosse to Greenville by plane, train, bus, car, taxi, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from La Crosse (LSE) to Greenville–Spartanburg International Airport (GSP)plane plane LSE - GSP
    5h 38m
    $163–666

  2. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    27h 39m
    $250–564

  3. Train, bus via Cary

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    4. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    38h 36m
    $523–1,154

  4. Drive 948.3 mi

    1. Drive from La Crosse to Greenvillecar car 948.3 mi
    17h 22m
    $174–250

  5. Fly to Asheville Regional Airport, taxi

    1. Fly from La Crosse (LSE) to Asheville Regional Airport (AVL)plane plane LSE - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    6h 11m
    $233–591

  6. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    29h 3m
    $234–485

  7. Bus via Bloomington

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    4. Take the bus from Bloomington to Atlanta Bus Stationbus bus
    5. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    29h 22m
    $238–475

La Crosse (LSE) to Greenville–Spartanburg International Airport (GSP) flights

Calendar21Weekly Planes
Duration6h 23mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Greenville.ExpandLaunch map view
  • Distance: 804.6 mi
  • Duration: 5h 38m

What companies run services between La Crosse, WI, USA and Greenville, SC, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Greenville–Spartanburg International Airport (GSP) 3 times a day. Alternatively, you can take a bus from La Crosse to Greenville via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, Atlanta Bus Station, Garnett Station, Lindbergh Center Station, Lindbergh Center Station - Bay D, Shallowford Rd @ New Peachtree, Atlanta, and Taqueria Guadalajara - Greenville in around 29h 3m.

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