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How to get fromLa Crosse to Hannibalby train (Amtrak), bus, train, car, plane, shuttle, or taxi

Find Transport to Hannibal

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There are 8 ways to get from La Crosse to Hannibal by train (Amtrak), bus, train, car, plane, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train Carl Sandburg / ...
    10h 59m
    $375–578

  2. Drive  323 mi

    cheapest
    1. Drive from La Crosse to Hannibalcar car 323 mi
    6h 16m
    $59–86

  3. Bus, train

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    12h 47m
    $285–453

  4. Fly La Crosse to Columbia Regional Airport, shuttle

    1. Fly from La Crosse (LSE) to Columbia Regional Airport (COU)plane plane LSE - COU
    2. Take a shuttle bus from Columbia to Hannibalshuttle bus
    7h 22m
    $143–475

  5. Fly La Crosse to Quincy Regional Airport, taxi

    1. Fly from La Crosse (LSE) to Quincy Regional Airport (UIN)plane plane LSE - UIN
    2. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    8h 28m
    $183–561

  6. Train to Minneapolis–Saint Paul International Airport, fly to The Eastern Iowa Airport, drive

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to The Eastern Iowa Airport (CID)plane plane MSP - CID
    3. Drive from Cedar-Rapids-Airport-CID to Hannibalcar car
    8h 40m
    $153–527

  7. Train to Minneapolis–Saint Paul International Airport, fly to Lambert–St. Louis International Airport, shuttle

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    3. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    9h 12m
    $181–735

  8. Fly La Crosse to Burlington Municipal Airport, drive

    1. Fly from La Crosse (LSE) to Burlington Municipal Airport (BRL)plane plane LSE - BRL
    2. Drive from Burlington Municipal Airport (BRL) to Hannibalcar car
    9h 27m
    $89–386

La Crosse (LSE) to Columbia Regional Airport (COU) flights

Calendar14Weekly Planes
Duration4h 44mAverage Duration
Ticket$62Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Hannibal.ExpandLaunch map view
  • Distance: 609.1 mi
  • Duration: 10h 59m

What companies run services between La Crosse, WI, USA and Hannibal, MO, USA?

You can take a train from La Crosse Amtrak Station to Hannibal via Chicago Union Station and Quincy Amtrak Station in around 10h 59m.

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