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How to get fromLa Crosse to Indianaby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound, Amtrak)

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There are 6 ways to get from La Crosse to Indiana by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to South Bend

    best
    1. Fly from La Crosse (LSE) to South Bend (SBN)plane plane LSE - SBN
    4h 10m
    $103–499

  2. Fly to Chicago O'Hare International Airport, train

    cheapest
    1. Fly from La Crosse (LSE) to Chicago O'Hare International Airport (ORD)plane plane LSE - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 40m
    $57–265

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    11h 2m
    $152–314

  4. Bus

    1. Take the bus from University of Wisconsin - La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Indianapolisbus bus
    12h 5m
    $101–157

  5. Drive 459.7 mi

    1. Drive from La Crosse to Indianapoliscar car 459.7 mi
    7h 51m
    $84–122

  6. Bus via Madison

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Train Station to Indianapolis Union Stationbus bus
    12h 48m
    $98–168

La Crosse to Indiana by train (Amtrak)

Calendar3Weekly Trains
Duration11h 2mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Indiana.ExpandLaunch map view
  • Distance: 303.5 mi
  • Duration: 4h 10m

What companies run services between La Crosse, WI, USA and Indiana, USA?

United Airlines and American Airlines fly from La Crosse (LSE) to South Bend (SBN) 4 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Indianapolis via Chicago Union Station in around 11h 2m.

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