There are 6 ways to get from La Crosse to Indiana by plane, train, train (Amtrak), bus (Flixbus), car, or bus (Amtrak, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Chicago O'Hare International Airport, train
best- Fly from La Crosse (LSE) to Chicago O'Hare International Airport (ORD)plane LSE - ORD
- Take the train from Van Buren St. to Gary Metro Centertrain
3h 35m$58–276Train (Amtrak)
- Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain Empire Builder / ...
- Take the train from Chicago Union Station to Indianapolistrain Cardinal
11h 2m$115–280Bus via Milwaukee Airport (MKE)
- Take the bus from La Crosse to Milwaukeebus Jefferson Lines 965
- Take the bus from Milwaukee Mitchell Airport to Indianapolisbus FlixBus 2511
11h 14m$97–149Drive 459.7 mi
- Drive from La Crosse to Indianapoliscar 459.7 mi
7h 51m$84–122Fly to South Bend, train
- Fly from La Crosse (LSE) to South Bend (SBN)plane LSE - SBN
- Take the train from South Bend Airport to Gary Metro Centertrain
6h 13m$99–514Bus
- Take the bus from La Crosse to Madisonbus
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus
- Take the bus from Chicago Union Station to Indianapolis Union Stationbus
11h 46m$93–158
La Crosse to Indiana by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from La Crosse to Indiana is to drive which costs $80 - $130 and takes 7h 51m.
The fastest way to get from La Crosse to Indiana is to fly and train which takes 3h 35m and costs $55 - $280.
No, there is no direct bus from La Crosse to Indiana. However, there are services departing from La Crosse and arriving at Indianapolis via N6 & Clybourn and Milwaukee Mitchell Airport. The journey, including transfers, takes approximately 11h 14m.
No, there is no direct train from La Crosse station to Indiana. However, there are services departing from La Crosse Amtrak Station and arriving at Indianapolis via Chicago Union Station. The journey, including transfers, takes approximately 11h 2m.
The distance between La Crosse and Indiana is 271 miles. The road distance is 462.4 miles.
The best way to get from La Crosse to Indiana without a car is to train which takes 11h 2m and costs $110 - $280.
It takes approximately 3h 35m to get from La Crosse to Indiana, including transfers.
La Crosse to Indiana bus services, operated by Jefferson Lines, depart from La Crosse station.
La Crosse to Indiana train services, operated by Amtrak, depart from La Crosse Amtrak Station.
The best way to get from La Crosse to Indiana is to train which takes 11h 2m and costs $110 - $280. Alternatively, you can bus via Milwaukee Airport (MKE), which costs $95 - $150 and takes 11h 14m.
What companies run services between La Crosse, WI, USA and Indiana, USA?
You can take a train from La Crosse Amtrak Station to Indianapolis via Chicago Union Station in around 11h 2m. Alternatively, you can take a bus from La Crosse to Indianapolis via Milwaukee, N6 & Clybourn, Airport Departure, and Milwaukee Mitchell Airport in around 11h 14m.
- Website
- united.com
Flights from La Crosse to Chicago O'Hare International Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $30–240
Flights from La Crosse to South Bend via Chicago O'Hare International Airport
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $70–480
- Phone
- +1 219-926-5744
- Website
- mysouthshoreline.com
Train from Van Buren St. to Gary Metro Center
- Ave. Duration
- 51 min
- Frequency
- Every 30 minutes
- Estimated price
- $8–10
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $8–10
Train from South Bend Airport to Gary Metro Center
- Ave. Duration
- 1h 11m
- Frequency
- Every 4 hours
- Estimated price
- $11–13
- Schedules at
- mysouthshoreline.com
- Adults 14-64
- $11–13
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from La Crosse to Milwaukee
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from La Crosse to Madison
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $35–55
- Book at
- Jefferson Lines
- Adult
- $35–55
Want to know more about travelling around United States
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Booking & Getting There
La Crosse to Indiana bus services, operated by Jefferson Lines, arrive at Milwaukee station.
Indiana is 1h ahead of La Crosse. It is currently 4:03 PM in La Crosse and 5:03 PM in Indiana.
La Crosse to Indiana train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between La Crosse to Indiana is 462 miles. It takes approximately 7h 51m to drive from La Crosse to Indiana.
Book your La Crosse to Indiana train tickets online with Omio.
There are 875+ hotels available in Indiana.



