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How to get fromLa Crosse to Indianaby plane, train, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Amtrak, Greyhound)

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There are 6 ways to get from La Crosse to Indiana by plane, train, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago O'Hare International Airport, train

    best
    1. Fly from La Crosse (LSE) to Chicago O'Hare International Airport (ORD)plane plane LSE - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 38m
    $58–266

  2. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    11h 2m
    $127–335

  3. Bus via Milwaukee

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Indianapolisbus bus
    11h 10m
    $95–143

  4. Drive  459.7 mi

    1. Drive from La Crosse to Indianapoliscar car 459.7 mi
    7h 51m
    $84–122

  5. Fly to South Bend, train

    1. Fly from La Crosse (LSE) to South Bend (SBN)plane plane LSE - SBN
    2. Take the train from South Bend Airport to Gary Metro Centertrain train
    6h
    $94–494

  6. Bus

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Indianapolis Union Stationbus bus
    11h 46m
    $94–163

La Crosse to Indiana by train (Amtrak)

Calendar3Weekly Trains
Duration11h 2mAverage Duration
Ticket$127Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Indiana.ExpandLaunch map view
  • Distance: 269.3 mi
  • Duration: 3h 38m

What companies run services between La Crosse, WI, USA and Indiana, USA?

You can take a train from La Crosse Amtrak Station to Indianapolis via Chicago Union Station in around 11h 2m. Alternatively, you can take a bus from La Crosse to Indianapolis via Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 11h 10m.

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