There are 5 ways to get from La Crosse to Indianapolis by plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Amtrak, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from La Crosse (LSE) to Indianapolis (IND)plane LSE - IND
5h 30m$95–503Drive 459.7 mi
cheapest- Drive from La Crosse to Indianapoliscar 459.7 mi
7h 51m$84–122Train (Amtrak)
- Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain Empire Builder / ...
- Take the train from Chicago Union Station to Indianapolistrain Cardinal
11h 2m$255–407Bus via Milwaukee
- Take the bus from La Crosse to Milwaukeebus
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Indianapolisbus
11h 10m$96–143Bus
- Take the bus from La Crosse to Madisonbus
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus
- Take the bus from Chicago Union Station to Indianapolis Union Stationbus
11h 46m$95–163
La Crosse to Indianapolis by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from La Crosse to Indianapolis is to drive which costs $80 - $130 and takes 7h 51m.
The fastest way to get from La Crosse to Indianapolis is to fly which takes 5h 30m and costs $95 - $550.
No, there is no direct bus from La Crosse to Indianapolis. However, there are services departing from La Crosse and arriving at Indianapolis via Milwaukee Intermodal Station and Chicago Bus Station. The journey, including transfers, takes approximately 11h 10m.
No, there is no direct train from La Crosse station to Indianapolis. However, there are services departing from La Crosse Amtrak Station and arriving at Indianapolis via Chicago Union Station. The journey, including transfers, takes approximately 11h 2m.
The distance between La Crosse and Indianapolis is 409 miles. The road distance is 462.4 miles.
The best way to get from La Crosse to Indianapolis without a car is to train which takes 11h 2m and costs $250 - $410.
It takes approximately 5h 30m to get from La Crosse to Indianapolis, including transfers.
La Crosse to Indianapolis bus services, operated by Jefferson Lines, depart from La Crosse station.
La Crosse to Indianapolis train services, operated by Amtrak, depart from La Crosse Amtrak Station.
The best way to get from La Crosse to Indianapolis is to fly which takes 5h 30m and costs $95 - $550. Alternatively, you can train, which costs $250 - $410 and takes 11h 2m, you could also bus via Milwaukee, which costs $95 - $150 and takes 11h 10m.
What companies run services between La Crosse, WI, USA and Indianapolis, IN, USA?
American Airlines flies from La Crosse (LSE) to Indianapolis (IND) 4 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Indianapolis via Chicago Union Station in around 11h 2m.
- Website
- aa.com
Flights from La Crosse to Indianapolis via Chicago O'Hare
- Ave. Duration
- 5h 22m
- When
- Every day
- Estimated price
- $75–480
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from La Crosse Amtrak Station to Chicago Union Station
- Ave. Duration
- 5h 8m
- Frequency
- 3 times a day
- Estimated price
- $150–240
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $100–170
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from La Crosse to Milwaukee
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from La Crosse to Madison
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $35–55
- Book at
- Jefferson Lines
- Adult
- $35–55
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- $15–23
- Website
- Greyhound
Bus from Chicago Union Station to Indianapolis Union Station
- Ave. Duration
- 3h 50m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $13–21
- Schedules at
- Flixbus USA
Bus from Chicago Bus Station to Indianapolis
- Ave. Duration
- 3h 45m
- Frequency
- Every 4 hours
- Estimated price
- $28–45
- Schedules at
- Flixbus USA
- Phone
- +1 (866) 912 - 6224
- [email protected]
- Website
- Rockland Coaches
Bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton St
- Ave. Duration
- 4h
- Frequency
- Hourly
- Estimated price
- $26–60
- Schedules at
- Rockland Coaches
- Adult
- $26–60
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Chicago Union Station to Indianapolis Union Station
- Ave. Duration
- 3h 50m
- Frequency
- Twice daily
- Estimated price
- $35–50
- Website
- Amtrak
- Adult
- $35–50
Want to know more about travelling around United States
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Booking & Getting There
La Crosse to Indianapolis bus services, operated by Jefferson Lines, arrive at Milwaukee station.
Indianapolis is 1h ahead of La Crosse. It is currently 4:20 AM in La Crosse and 5:20 AM in Indianapolis.
La Crosse to Indianapolis train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between La Crosse to Indianapolis is 462 miles. It takes approximately 7h 51m to drive from La Crosse to Indianapolis.
Book your La Crosse to Indianapolis train tickets online with Omio.
Book your La Crosse to Indianapolis bus tickets online with Omio.
There are 889+ hotels available in Indianapolis.