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How to get fromLa Crosse to Indianapolisby plane, train (Amtrak), bus, car, or bus (Greyhound)

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There are 5 ways to get from La Crosse to Indianapolis by plane, train (Amtrak), bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from La Crosse (LSE) to Indianapolis (IND)plane plane LSE - IND
    5h 40m
    $95–473
  2. Drive 459.7 mi

    cheapest
    1. Drive from La Crosse to Indianapoliscar car 459.7 mi
    7h 51m
    $84–122
  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    11h 2m
    $151–313
  4. Bus

    1. Take the bus from La Crosse to UW-Madisonbus bus Minneapolis / ...
    2. Take the bus from Madison to Indianapolisbus bus FlixBus 2514
    11h 25m
  5. Bus via Chicago

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus
    11h 49m
    $96–173

La Crosse to Indianapolis by train (Amtrak)

Calendar3Weekly Trains
Duration11h 2mAverage Duration
Ticket$151Cheapest Price
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Questions & Answers

What companies run services between La Crosse, WI, USA and Indianapolis, IN, USA?

United Airlines and American Airlines fly from La Crosse (LSE) to Indianapolis (IND) 4 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Indianapolis via Chicago Union Station in around 11h 2m.

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