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How to get fromLa Crosse to Jacksonvilleby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 5 ways to get from La Crosse to Jacksonville by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to Jacksonville (JAX)plane plane LSE - JAX
    6h 29m
    $129–574

  2. Bus

    1. Take the bus from La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    32h 10m
    $236–436

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    41h 49m
    $592–1,288

  4. Drive 1,263.7 mi

    1. Drive from La Crosse to Jacksonvillecar car 1,263.7 mi
    22h 40m
    $231–334

  5. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Jacksonville (JAX)plane plane MSP - JAX
    8h 58m
    $185–741

La Crosse to Jacksonville by bus

Calendar21Weekly Buses
Duration32h 10mAverage Duration
Ticket$236Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Jacksonville.ExpandLaunch map view
  • Distance: 1,087.4 mi
  • Duration: 6h 29m

What companies run services between La Crosse, WI, USA and Jacksonville, FL, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Jacksonville (JAX) 5 times a day. Alternatively, you can take a bus from La Crosse to Jacksonville via Milwaukee Intermodal Station, Chicago Bus Station, and Atlanta Bus Station in around 32h 10m.

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