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How to get fromLa Crosse to Key Westby plane, bus (Greyhound, Flixbus), train, bus, or car

Find Transport to Key West

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There are 6 ways to get from La Crosse to Key West by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to Key West International Airport (EYW)plane plane LSE - EYW
    8h 52m
    $114–424

  2. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    6. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    44h 46m
    $314–529

  3. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 12h
    $1,283–2,083

  4. Drive  1,754.3 mi

    1. Drive from La Crosse to Key Westcar car 1,754.3 mi
    31h 12m
    $300–434

  5. Bus to Dane County Regional Airport-Truax Field, fly

    1. Take the bus from La Crosse to Madisonbus bus
    2. Fly from Dane County Regional Airport-Truax Field (MSN) to Key West International Airport (EYW)plane plane MSN - EYW
    9h 17m
    $132–438

  6. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Key West International Airport (EYW)plane plane MSP - EYW
    10h 34m
    $204–495

La Crosse to Key West by bus and foot

Calendar7Weekly Services
Duration44h 46mAverage Duration
Ticket$314Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Key West.ExpandLaunch map view
  • Distance: 1,447.7 mi
  • Duration: 8h 52m

What companies run services between La Crosse, WI, USA and Key West, FL, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Key West International Airport (EYW) 3 times a day. Alternatively, you can take a bus from La Crosse to N Roosevelt & 3rd Street via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 44h 46m.

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