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How to get fromLa Crosse to Knoxvilleby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus)

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There are 7 ways to get from La Crosse to Knoxville by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from La Crosse (LSE) to Mcghee Tyson Airport (TYS)plane plane LSE - TYS
    6h 1m
    $203–791

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from La Crosse (LSE) to Asheville Regional Airport (AVL)plane plane LSE - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 23m
    $115–456

  3. Bus via Milwaukee

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    38h 11m
    $391–594

  4. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 53m
    $573–1,087

  5. Drive 806.5 mi

    1. Drive from La Crosse to Knoxvillecar car 806.5 mi
    13h 49m
    $148–213

  6. Train, bus via Ossining

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 30m
    $528–1,014

  7. Bus

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    46h 1m
    $314–498

La Crosse (LSE) to Mcghee Tyson Airport (TYS) flights

Calendar30Weekly Planes
Duration5h 49mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Knoxville.ExpandLaunch map view
  • Distance: 697 mi
  • Duration: 6h 1m

What companies run services between La Crosse, WI, USA and Knoxville, TN, USA?

American Airlines, Allegiant Air, and United Airlines fly from La Crosse (LSE) to Mcghee Tyson Airport (TYS) 4 times a day. Alternatively, you can take a bus from La Crosse to Knoxville via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 38h 11m.

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