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How to get fromLa Crosse to Lafayetteby train (Amtrak), bus, shuttle, car, plane, bus (Amtrak), or train

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There are 7 ways to get from La Crosse to Lafayette by train (Amtrak), bus, shuttle, car, plane, bus (Amtrak), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    9h 9m
    $122–262

  2. Fly to Purdue University Airport

    cheapest
    1. Fly from La Crosse (LSE) to Purdue University Airport (LAF)plane plane LSE - LAF
    4h 29m
    $69–342

  3. Bus, shuttle

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 2 Departuresbus bus
    3. Take a shuttle bus from O'Hare International Terminal 2 to West Lafayette, INshuttle bus
    10h 31m
    $92–163

  4. Drive 401.5 mi

    1. Drive from La Crosse to Lafayettecar car 401.5 mi
    6h 50m
    $74–106

  5. Fly to Indianapolis, shuttle

    1. Fly from La Crosse (LSE) to Indianapolis (IND)plane plane LSE - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    6h 20m
    $107–516

  6. Bus

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus
    10h 38m
    $88–158

  7. Fly to Chicago O'Hare International Airport, train

    1. Fly from La Crosse (LSE) to Chicago O'Hare International Airport (ORD)plane plane LSE - ORD
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    6h 35m
    $85–346

La Crosse to Lafayette by train (Amtrak)

Calendar3Weekly Trains
Duration9h 9mAverage Duration
Ticket$122Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Lafayette.ExpandLaunch map view
  • Distance: 400.4 mi
  • Duration: 9h 9m

What companies run services between La Crosse, WI, USA and Lafayette, IN, USA?

You can take a train from La Crosse Amtrak Station to Lafayette Amtrak Station via Chicago Union Station in around 9h 9m. Alternatively, you can take a bus from La Crosse to Lafayette Amtrak Station via Madison, 250 N. Lake St - Madison UW Campus, W Jackson Blvd, after S Clinton St, and Chicago Union Station in around 10h 38m.

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