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How to get fromLa Crosse to Lawrenceby bus (Greyhound, Flixbus), train (Amtrak), car, plane, train, or bus

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There are 7 ways to get from La Crosse to Lawrence by bus (Greyhound, Flixbus), train (Amtrak), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Rochester

    best
    1. Take the bus from La Crosse to Rochesterbus bus
    2. Take the bus from Rochester to Owatonnabus bus
    3. Take the bus from Owatonna to Kansas Citybus bus
    4. Take the bus from Kansas City Bus Station to Lawrence Bus Stopbus bus
    14h 19m
    $129–220

  2. Drive  469.6 mi

    cheapest
    1. Drive from La Crosse to Lawrencecar car 469.6 mi
    8h 48m
    $86–124

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Lawrence Amtrak Stationtrain train Southwest Chief
    15h 8m
    $193–440

  4. Fly from La Crosse, train

    1. Fly from La Crosse (LSE) to Kansas City (MCI)plane plane LSE - MCI
    2. Take the train from Kansas City to Lawrence Amtrak Stationtrain train
    9h 13m
    $128–644

  5. Bus

    1. Take the bus from La Crosse to St. Paulbus bus
    2. Take the bus from Saint Paul Union Depot to Kansas City Bus Stationbus bus
    3. Take the bus from Kansas City Bus Station to Lawrence Bus Stopbus bus
    15h 15m
    $150–221

  6. Train to Minneapolis–Saint Paul International Airport, fly, train

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Kansas City (MCI)plane plane MSP - MCI
    3. Take the train from Kansas City to Lawrence Amtrak Stationtrain train
    10h 22m
    $546–1,050

  7. Bus to Rochester, fly, train

    1. Take the bus from La Crosse to Rochesterbus bus
    2. Fly from Rochester (RST) to Kansas City (MCI)plane plane RST - MCI
    3. Take the train from Kansas City to Lawrence Amtrak Stationtrain train
    11h 53m
    $124–652

La Crosse to Lawrence by bus

Calendar7Weekly Buses
Duration14h 19mAverage Duration
Ticket$129Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Lawrence.ExpandLaunch map view
  • Distance: 537.3 mi
  • Duration: 14h 19m

What companies run services between La Crosse, WI, USA and Lawrence, KS, USA?

You can take a bus from La Crosse to Lawrence Bus Stop via Rochester, Owatonna, Kansas City, and Kansas City Bus Station in around 14h 19m. Alternatively, you can take a train from La Crosse Amtrak Station to Lawrence Amtrak Station via Chicago Union Station in around 15h 8m.

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