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How to get fromLa Crosse to Lexingtonby plane, car, train, bus, or bus (Greyhound, Flixbus)

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There are 7 ways to get from La Crosse to Lexington by plane, car, train, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Louisville International Airport, drive

    best
    1. Fly from La Crosse (LSE) to Louisville International Airport (SDF)plane plane LSE - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 51m
    $117–522

  2. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    16h 4m

  3. Bus via Indianapolis

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from Madison to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    17h 32m

  4. Drive 642.6 mi

    1. Drive from La Crosse to Lexingtoncar car 642.6 mi
    11h 12m
    $118–170

  5. Fly La Crosse to Blue Grass Airport

    1. Fly from La Crosse (LSE) to Blue Grass Airport (LEX)plane plane LSE - LEX
    6h 56m
    $150–773

  6. Train to Minneapolis–Saint Paul International Airport, fly to Louisville International Airport, drive

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Louisville International Airport (SDF)plane plane MSP - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    7h 57m
    $168–708

  7. Bus

    1. Take the bus from La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Lexington Bus Stopbus bus
    17h 34m

La Crosse (LSE) to Louisville International Airport (SDF) flights

Calendar14Weekly Planes
Duration5h 24mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Lexington.ExpandLaunch map view
  • Distance: 573.2 mi
  • Duration: 6h 51m

What companies run services between La Crosse, WI, USA and Lexington, KY, USA?

You can take a bus from La Crosse to Centre Parkway @ 1349 via Madison, Indianapolis, Indianapolis Union Station, Lexington Bus Stop, and Transit Center in around 17h 32m. Alternatively, American Airlines and United Airlines fly from La Crosse (LSE) to Blue Grass Airport (LEX) 4 times a day.

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