Rome2Rio

How to get fromLa Crosse to Lexingtonby plane, car, train, or bus

Find Transport to Lexington

See all options

There are 9 ways to get from La Crosse to Lexington by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Covington, drive

    best
    1. Fly from La Crosse (LSE) to Covington (CVG)plane plane LSE - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    6h 5m
    $128–643

  2. Fly to Blue Grass Airport

    cheapest
    1. Fly from La Crosse (LSE) to Blue Grass Airport (LEX)plane plane LSE - LEX
    7h 42m
    $80–393

  3. Train, bus, drive

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    16h
    $123–262

  4. Train, bus, drive via Lafayette (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    18h 2m
    $142–312

  5. Drive  642.6 mi

    1. Drive from La Crosse to Lexingtoncar car 642.6 mi
    11h 13m
    $118–170

  6. Fly to Louisville International Airport, drive

    1. Fly from La Crosse (LSE) to Louisville International Airport (SDF)plane plane LSE - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 41m
    $132–692

  7. Train, bus, drive via Gary

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3. Take the bus from Gary Bus Station to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    16h 19m
    $134–265

  8. Bus, drive

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    17h 8m
    $122–196

  9. Bus, drive via Bloomington

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    4. Take the bus from Bloomington to Louisville Bus Stationbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    19h 51m
    $122–213

La Crosse (LSE) to Covington (CVG) flights

Calendar28Weekly Planes
Duration5h 18mAverage Duration
Ticket$99Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from La Crosse to Lexington.ExpandLaunch map view
  • Distance: 565.7 mi
  • Duration: 6h 5m

What companies run services between La Crosse, WI, USA and Lexington, KY, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Blue Grass Airport (LEX) twice daily.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound