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How to get fromLa Crosse to Lexingtonby plane, car, train, or bus

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There are 8 ways to get from La Crosse to Lexington by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Covington, drive

    best
    1. Fly from La Crosse (LSE) to Covington (CVG)plane plane LSE - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    6h 27m
    $128–643

  2. Fly La Crosse to Blue Grass Airport

    cheapest
    1. Fly from La Crosse (LSE) to Blue Grass Airport (LEX)plane plane LSE - LEX
    6h 58m
    $80–393

  3. Train, bus, drive (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    17h 45m
    $217–317

  4. Train, bus, drive via Lafayette (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    18h 53m
    $263–420

  5. Drive  642.6 mi

    1. Drive from La Crosse to Lexingtoncar car 642.6 mi
    11h 13m
    $118–170

  6. Fly La Crosse to Louisville International Airport, drive

    1. Fly from La Crosse (LSE) to Louisville International Airport (SDF)plane plane LSE - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 56m
    $132–692

  7. Train to Minneapolis–Saint Paul International Airport, fly to Covington, drive

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Covington (CVG)plane plane MSP - CVG
    3. Drive from Covington (CVG) to Lexingtoncar car
    7h 49m
    $538–1,234

  8. Bus, drive

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    19h 40m
    $128–194

La Crosse (LSE) to Covington (CVG) flights

Calendar36Weekly Planes
Duration7h 11mAverage Duration
Ticket$97Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Lexington.ExpandLaunch map view
  • Distance: 565.7 mi
  • Duration: 6h 27m

What companies run services between La Crosse, WI, USA and Lexington, KY, USA?

American Airlines flies from La Crosse (LSE) to Blue Grass Airport (LEX) twice daily.

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