Rome2Rio

How to get fromLa Crosse to Louisvilleby plane, train, bus, bus (Amtrak), car, or bus (Flixbus)

Find Transport to Louisville

See all options

There are 6 ways to get from La Crosse to Louisville by plane, train, bus, bus (Amtrak), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from La Crosse (LSE) to Louisville International Airport (SDF)plane plane LSE - SDF
    6h 34m
    $104–524

  2. Train, bus (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    14h 27m
    $173–360

  3. Bus via Chicago

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Louisville, KYbus bus
    15h 58m
    $118–178

  4. Drive 574.4 mi

    1. Drive from La Crosse to Louisvillecar car 574.4 mi
    9h 42m
    $105–152

  5. Fly to Blue Grass Airport, drive

    1. Fly from La Crosse (LSE) to Blue Grass Airport (LEX)plane plane LSE - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 51m
    $161–790

  6. Bus

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from Madison to Cincinnatibus bus
    3. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    17h 7m
    $122–236

La Crosse to Louisville by train and bus (Amtrak)

Calendar3Weekly Services
Duration14h 27mAverage Duration
Ticket$173Cheapest Price
See schedules

Questions & Answers

Map of how to get from La Crosse to Louisville.ExpandLaunch map view
  • Distance: 499.8 mi
  • Duration: 6h 34m

What companies run services between La Crosse, WI, USA and Louisville, KY, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Louisville International Airport (SDF) twice daily. Alternatively, you can take a bus from La Crosse to Louisville, KY via 250 N. Lake St - Madison UW Campus, W Jackson Blvd, after S Clinton St, and Chicago Union Station in around 15h 58m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers