There are 8 ways to get from La Crosse to Missouri by plane, bus (Greyhound), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly La Crosse to Columbia Regional Airport
best- Fly from La Crosse (LSE) to Columbia Regional Airport (COU)plane LSE - COU
6h 2m$128–456Drive 430.7 mi
cheapest- Drive from La Crosse to Kansas Citycar 430.7 mi
8h 11m$79–114Bus
- Take the bus from La Crosse to St. Paulbus Jefferson Lines 966
- Take the bus from Saint Paul Union Depot to Kansas City Bus Stationbus Greyhound US0156
12h 30m$144–210Train (Amtrak)
- Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain Empire Builder / ...
- Take the train from Chicago Union Station to Kansas Citytrain Southwest Chief / ...
13h 43m$395–607Fly La Crosse to Lambert–St. Louis International Airport
- Fly from La Crosse (LSE) to Lambert–St. Louis International Airport (STL)plane LSE - STL
4h 50m$96–484Fly La Crosse to Springfield-Branson National Airport
- Fly from La Crosse (LSE) to Springfield-Branson National Airport (SGF)plane LSE - SGF
4h 43m$104–431Fly La Crosse to Kansas City
- Fly from La Crosse (LSE) to Kansas City (MCI)plane LSE - MCI
6h 22m$118–571Train to Minneapolis–Saint Paul International Airport, fly to Lambert–St. Louis International Airport
- Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain
- Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane MSP - STL
6h 41m$166–665
La Crosse to Missouri by bus
Comparing Your Travel Options
The cheapest way to get from La Crosse to Missouri is to drive which costs $75 - $120 and takes 8h 11m.
The fastest way to get from La Crosse to Missouri is to fly which takes 4h 43m and costs $100 - $440.
No, there is no direct bus from La Crosse to Missouri station. However, there are services departing from La Crosse and arriving at Kansas City Bus Station via Saint Paul Union Depot. The journey, including transfers, takes approximately 12h 30m.
No, there is no direct train from La Crosse station to Missouri. However, there are services departing from La Crosse Amtrak Station and arriving at Metro Center via Chicago Union Station and Union Station. The journey, including transfers, takes approximately 13h 43m.
The distance between La Crosse and Missouri is 375 miles. The road distance is 433.2 miles.
The best way to get from La Crosse to Missouri without a car is to bus which takes 12h 30m and costs $140 - $210.
It takes approximately 6h 2m to get from La Crosse to Missouri, including transfers.
La Crosse to Missouri bus services, operated by Jefferson Lines, depart from La Crosse station.
La Crosse to Missouri train services, operated by Amtrak, depart from La Crosse Amtrak Station.
The best way to get from La Crosse to Missouri is to fly which takes 6h 2m and costs $120 - $460. Alternatively, you can bus, which costs $140 - $210 and takes 12h 30m, you could also train, which costs $390 - $650 and takes 13h 43m.
What companies run services between La Crosse, WI, USA and Missouri, USA?
American Airlines flies from La Crosse (LSE) to Columbia Regional Airport (COU) twice daily. Alternatively, you can take a bus from La Crosse to Kansas City Bus Station via Saint Paul Union Depot in around 12h 30m.
- Website
- aa.com
Flights from La Crosse to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 31m
- When
- Every day
- Estimated price
- $60–370
Flights from La Crosse to Columbia Regional Airport via Chicago O'Hare, Dallas/Ft.Worth
- Ave. Duration
- 9h 38m
- When
- Every day
- Estimated price
- $120–550
Flights from La Crosse to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $75–460
Flights from La Crosse to Springfield-Branson National Airport via Chicago O'Hare
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $70–390
Flights from La Crosse to Kansas City via Chicago O'Hare
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $100–550
- Website
- delta.com
Flights from Minneapolis–Saint Paul International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $90–550
- Website
- southwest.com
Flights from Minneapolis–Saint Paul International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $90–550
Flights from Minneapolis–Saint Paul International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 35m
- When
- Tuesday to Friday
- Estimated price
- $100–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from La Crosse Amtrak Station to Chicago Union Station
- Ave. Duration
- 5h 8m
- Frequency
- 3 times a day
- Estimated price
- $150–240
- Website
- Amtrak
Train from Chicago Union Station to Kansas City
- Ave. Duration
- 7h 23m
- Frequency
- Twice daily
- Estimated price
- $240–370
- Website
- Amtrak
Train from La Crosse Amtrak Station to St. Paul-Minneapolis
- Ave. Duration
- 2h 52m
- Frequency
- 3 times a day
- Estimated price
- $70–110
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from La Crosse to St. Paul
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $40–65
- Book at
- Jefferson Lines
- Adult
- $40–65
Bus from Saint Paul Union Depot to Kansas City Bus Station
- Ave. Duration
- 8h 45m
- Frequency
- 4 times a week
- Estimated price
- $100–150
- Book at
- Jefferson Lines
- Adult
- $100–150
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Saint Paul Union Depot to Kansas City Bus Station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $75–120
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
La Crosse to Missouri bus services, operated by Jefferson Lines, arrive at St. Paul station.
La Crosse to Missouri train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between La Crosse to Missouri is 433 miles. It takes approximately 8h 11m to drive from La Crosse to Missouri.
There are 500+ hotels available in Missouri.