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How to get fromLa Crosse to Myrtle Beachby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 8 ways to get from La Crosse to Myrtle Beach by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Myrtle Beach

    best
    1. Fly from La Crosse (LSE) to Myrtle Beach (MYR)plane plane LSE - MYR
    7h 39m
    $109–445

  2. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    33h 10m
    $243–388

  3. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    36h 16m
    $744–1,252

  4. Drive  1,163.6 mi

    1. Drive from La Crosse to Myrtle Beachcar car 1,163.6 mi
    21h 43m
    $213–307

  5. Fly La Crosse to Wilmington International Airport, bus

    1. Fly from La Crosse (LSE) to Wilmington International Airport (ILM)plane plane LSE - ILM
    2. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    12h 46m
    $155–609

  6. Train to Minneapolis–Saint Paul International Airport, fly to Myrtle Beach

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Myrtle Beach (MYR)plane plane MSP - MYR
    7h 19m
    $184–676

  7. Bus to Dane County Regional Airport-Truax Field, fly to Myrtle Beach

    1. Take the bus from La Crosse to Madisonbus bus
    2. Fly from Dane County Regional Airport-Truax Field (MSN) to Myrtle Beach (MYR)plane plane MSN - MYR
    8h 27m
    $127–459

  8. Bus to Rochester, fly to Myrtle Beach

    1. Take the bus from La Crosse to Rochesterbus bus
    2. Fly from Rochester (RST) to Myrtle Beach (MYR)plane plane RST - MYR
    10h 58m
    $125–513

La Crosse to Myrtle Beach by bus

Calendar7Weekly Buses
Duration33h 10mAverage Duration
Ticket$243Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Myrtle Beach.ExpandLaunch map view
  • Distance: 975.9 mi
  • Duration: 7h 39m

What companies run services between La Crosse, WI, USA and Myrtle Beach, SC, USA?

American Airlines, United Airlines, and Southwest Airlines fly from La Crosse (LSE) to Myrtle Beach (MYR) 4 times a day. Alternatively, you can take a bus from La Crosse to Myrtle Beach Bus Station via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, and Atlanta Bus Station in around 33h 10m.

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