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How to get fromLa Crosse to Myrtle Beachby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 8 ways to get from La Crosse to Myrtle Beach by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Myrtle Beach

    best
    1. Fly from La Crosse (LSE) to Myrtle Beach (MYR)plane plane LSE - MYR
    6h 2m
    $109–415

  2. Bus

    1. Take the bus from La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    32h 32m
    $242–447

  3. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    4. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    37h 49m
    $506–1,053

  4. Drive 1,163 mi

    1. Drive from La Crosse to Myrtle Beachcar car 1,163 mi
    21h 44m
    $213–307

  5. Fly La Crosse to Wilmington International Airport, bus

    1. Fly from La Crosse (LSE) to Wilmington International Airport (ILM)plane plane LSE - ILM
    2. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    7h 52m
    $139–522

  6. Train to Minneapolis–Saint Paul International Airport, fly to Myrtle Beach

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Myrtle Beach (MYR)plane plane MSP - MYR
    7h 22m
    $155–571

  7. Bus to Rochester, fly to Myrtle Beach

    1. Take the bus from La Crosse to Rochester, MNbus bus
    2. Fly from Rochester (RST) to Myrtle Beach (MYR)plane plane RST - MYR
    9h 4m
    $199–803

  8. Train, bus via Raleigh

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    41h 52m
    $503–1,025

La Crosse to Myrtle Beach by bus

Calendar14Weekly Buses
Duration32h 32mAverage Duration
Ticket$242Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Myrtle Beach.ExpandLaunch map view
  • Distance: 975.9 mi
  • Duration: 6h 2m

What companies run services between La Crosse, WI, USA and Myrtle Beach, SC, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Myrtle Beach (MYR) 3 times a week. Alternatively, you can take a bus from La Crosse to Myrtle Beach Bus Station via Milwaukee Intermodal Station, Chicago Bus Station, and Atlanta Bus Station in around 32h 32m.

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