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How to get fromLa Crosse to Niagara Fallsby plane, bus, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

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There are 9 ways to get from La Crosse to Niagara Falls by plane, bus, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Buffalo Niagara International Airport, bus

    best
    1. Fly from La Crosse (LSE) to Buffalo Niagara International Airport (BUF)plane plane LSE - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    6h 12m
    $143–680

  2. Fly La Crosse to Toronto Island Airport, bus

    cheapest
    1. Fly from La Crosse (LSE) to Toronto Island Airport (YTZ)plane plane LSE - YTZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    9h 6m
    $90–416

  3. Train

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    3. Take the train from Buffalo Depew Station to Niagara Falls Amtrak Stationtrain train
    18h 32m
    $271–685

  4. Bus via Chicago

    1. Take the bus from La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    21h 10m
    $121–248

  5. Drive 801.7 mi

    1. Drive from La Crosse to Niagara Fallscar car 801.7 mi
    13h 24m
    $147–212

  6. Fly La Crosse to Toronto Pearson International Airport, bus

    1. Fly from La Crosse (LSE) to Toronto Pearson International Airport (YYZ)plane plane LSE - YYZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    8h 18m
    $91–405

  7. Fly La Crosse to Rochester, bus

    1. Fly from La Crosse (LSE) to Rochester (ROC)plane plane LSE - ROC
    2. Take the bus from Rochester Bus Stop to Niagara Falls USAbus bus
    9h 14m
    $171–719

  8. Train to Minneapolis–Saint Paul International Airport, fly to Buffalo Niagara International Airport, bus

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Buffalo Niagara International Airport (BUF)plane plane MSP - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    8h 25m
    $199–897

  9. Bus

    1. Take the bus from La Crosse Grand River Station to Appleton Valley Transitbus bus
    2. Take the bus from Appleton Transit Center to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Torontobus bus
    4. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    25h 5m
    $157–293

La Crosse to Niagara Falls by train

Calendar14Weekly Trains
Duration18h 32mAverage Duration
Ticket$271Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Niagara Falls.ExpandLaunch map view
  • Distance: 669.9 mi
  • Duration: 6h 12m

What companies run services between La Crosse, WI, USA and Niagara Falls, NY, USA?

You can take a train from La Crosse Amtrak Station to Niagara Falls Amtrak Station via Chicago Union Station and Buffalo Depew Station in around 18h 32m. Alternatively, you can take a bus from La Crosse to Main Street & Pine Avenue via Milwaukee Intermodal Station, Chicago Bus Station, Cleveland Bus Station, Cleveland, OH, and Ellicott Street & MTC Static in around 21h 10m.

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