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How to get fromLa Crosse to Paducahby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from La Crosse to Paducah by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Williamson County Regional Airport, bus

    best
    1. Fly from La Crosse (LSE) to Williamson County Regional Airport (MWA)plane plane LSE - MWA
    2. Take the bus from Carbondale Intermodal Station to Paducah Bus Stationbus bus
    6h 44m
    $128–449

  2. Drive  571.1 mi

    cheapest
    1. Drive from La Crosse to Paducahcar car 571.1 mi
    11h 4m
    $98–141

  3. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the bus from Carbondale Intermodal Station to Paducah Bus Stationbus bus
    13h 52m
    $344–524

  4. Bus, train

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Carbondaletrain train
    4. Take the bus from Carbondale Intermodal Station to Paducah Bus Stationbus bus
    15h 40m
    $255–401

  5. Fly La Crosse to Barkley Regional Airport

    1. Fly from La Crosse (LSE) to Barkley Regional Airport (PAH)plane plane LSE - PAH
    8h 15m
    $109–423

  6. Train to Chicago O'Hare International Airport, fly to Barkley Regional Airport

    1. Take the train from La Crosse Amtrak Station to Glenview Amtrak Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    8h 42m
    $215–532

  7. Fly La Crosse to Cape Girardeau Municipal Airport, drive

    1. Fly from La Crosse (LSE) to Cape Girardeau Municipal Airport (CGI)plane plane LSE - CGI
    2. Drive from Cape Girardeau Municipal Airport (CGI) to Paducahcar car
    8h 55m
    $150–590

  8. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Paducah Bus Stationbus bus
    17h 29m
    $155–225

La Crosse (LSE) to Williamson County Regional Airport (MWA) flights

Calendar12Weekly Planes
Duration4h 46mAverage Duration
Ticket$62Cheapest Price
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Comparing Your Travel Options

Map of how to get from La Crosse to Paducah.ExpandLaunch map view
  • Distance: 532.1 mi
  • Duration: 6h 44m

What companies run services between La Crosse, WI, USA and Paducah, KY, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Barkley Regional Airport (PAH) twice daily. Alternatively, you can take a bus from La Crosse to Paducah via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, St Louis Bus Station, and Paducah Bus Station in around 17h 29m.

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