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How to get fromLa Crosse to Pittsburghby plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 5 ways to get from La Crosse to Pittsburgh by plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from La Crosse (LSE) to Pittsburgh International Airport (PIT)plane plane LSE - PIT
    6h 17m
    $98–441

  2. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    15h 33m
    $241–503

  3. Bus

    1. Take the bus from La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Pittsburgh Intermodal Stationbus bus
    18h 47m
    $147–258

  4. Drive 740.8 mi

    1. Drive from La Crosse to Pittsburghcar car 740.8 mi
    12h 14m
    $136–196

  5. Bus via Madison

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago to Pittsburgh Intermodal Stationbus bus
    19h 51m
    $158–266

La Crosse to Pittsburgh by train (Amtrak)

Calendar7Weekly Trains
Duration15h 33mAverage Duration
Ticket$241Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Pittsburgh.ExpandLaunch map view
  • Distance: 641.7 mi
  • Duration: 6h 17m

What companies run services between La Crosse, WI, USA and Pittsburgh, PA, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Pittsburgh International Airport (PIT) 4 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Pittsburgh Amtrak Station via Chicago Union Station in around 15h 33m.

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