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How to get fromLa Crosse to Portlandby plane, train, bus, bus (Greyhound, Flixbus, Amtrak), or car

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There are 6 ways to get from La Crosse to Portland by plane, train, bus, bus (Greyhound, Flixbus, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to Portland (PWM)plane plane LSE - PWM
    6h 49m
    $128–571

  2. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Bostontrain train
    3. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    30h 25m
    $430–929

  3. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York Midtown to Bostonbus bus
    5. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    31h 26m
    $259–446

  4. Drive 1,316.3 mi

    1. Drive from La Crosse to Portlandcar car 1,316.3 mi
    23h 54m
    $241–347

  5. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Portland (PWM)plane plane MSP - PWM
    7h 17m
    $173–738

  6. Bus, train

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Bostontrain train
    4. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    32h 25m
    $406–858

La Crosse to Portland by train and bus

Calendar7Weekly Services
Duration30h 25mAverage Duration
Ticket$430Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to Portland.ExpandLaunch map view
  • Distance: 1,049.7 mi
  • Duration: 6h 49m

What companies run services between La Crosse, WI, USA and Portland, ME, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Portland (PWM) twice daily. Alternatively, you can take a bus from La Crosse to Portland, ME via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, New York Midtown, Boston, and Boston, MA - South Station in around 31h 26m.

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