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How to get fromLa Crosse to San Diegoby plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus

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There are 7 ways to get from La Crosse to San Diego by plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to San Diego International Airport (SAN)plane plane LSE - SAN
    7h 17m
    $188–721

  2. Bus to Rochester, fly

    cheapest
    1. Take the bus from La Crosse to Rochesterbus bus
    2. Fly from Rochester (RST) to San Diego International Airport (SAN)plane plane RST - SAN
    9h 37m
    $169–729

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    3. Take the train from Fullerton Amtrak Station to San Diegotrain train
    2d 4h
    $819–1,754

  4. Bus

    1. Take the bus from La Crosse to Minneapolisbus bus
    2. Take the bus from Minneapolis to Tulsabus bus
    3. Take the bus from Tulsa Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to San Diegobus bus
    2d 11h
    $456–773

  5. Drive 1,967.7 mi

    1. Drive from La Crosse to San Diegocar car 1,967.7 mi
    31h 58m
    $360–519

  6. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to San Diego International Airport (SAN)plane plane MSP - SAN
    8h 18m
    $253–638

  7. Train to General Mitchell International Airport, fly

    1. Take the train from La Crosse Amtrak Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to San Diego International Airport (SAN)plane plane MKE - SAN
    8h 53m
    $284–1,042

La Crosse to San Diego by train (Amtrak)

Calendar7Weekly Trains
Duration2d 4hAverage Duration
Ticket$819Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to San Diego.ExpandLaunch map view
  • Distance: 1,600.2 mi
  • Duration: 7h 17m

What companies run services between La Crosse, WI, USA and San Diego, CA, USA?

United Airlines and American Airlines fly from La Crosse (LSE) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a train from La Crosse Amtrak Station to San Diego via Chicago Union Station and Fullerton Amtrak Station in around 2d 4h.

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