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How to get fromLa Crosse to San Franciscoby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

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There are 7 ways to get from La Crosse to San Francisco by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to San Francisco International Airport

    best
    1. Fly from La Crosse (LSE) to San Francisco International Airport (SFO)plane plane LSE - SFO
    8h 14m
    $147–513

  2. Bus to Rochester, fly to San Francisco International Airport

    cheapest
    1. Take the bus from La Crosse to Rochesterbus bus
    2. Fly from Rochester (RST) to San Francisco International Airport (SFO)plane plane RST - SFO
    10h 52m
    $138–511

  3. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Denver Union Stationbus bus
    4. Take the bus from Denver Union Station to Sparks Transit Centerbus bus
    5. Take the bus from Sparks Transit Center to San Francisco Bus Stationbus bus
    2d 9h
    $413–761

  4. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Richmondtrain train California Zephyr
    2d 11h
    $843–1,791

  5. Drive 1,994.8 mi

    1. Drive from La Crosse to San Franciscocar car 1,994.8 mi
    32h 28m
    $364–526

  6. Train to Minneapolis–Saint Paul International Airport, fly to San Francisco International Airport

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to San Francisco International Airport (SFO)plane plane MSP - SFO
    9h 2m
    $172–420

  7. Train to Minneapolis–Saint Paul International Airport, fly to Norman Y. Mineta San José International Airport, Caltrain

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Norman Y. Mineta San José International Airport (SJC)plane plane MSP - SJC
    3. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    10h 23m
    $495–753

La Crosse to San Francisco by bus

Calendar7Weekly Buses
Duration2d 9hAverage Duration
Ticket$413Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to San Francisco.ExpandLaunch map view
  • Distance: 1,695.5 mi
  • Duration: 8h 14m

What companies run services between La Crosse, WI, USA and San Francisco, CA, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to San Francisco International Airport (SFO) every 4 hours. Alternatively, you can take a bus from La Crosse to San Francisco Bus Station via Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, Denver Union Station, and Sparks Transit Center in around 2d 9h.

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