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How to get fromLa Crosse to South Carolinaby plane, train (Amtrak), car, taxi, bus, or train

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There are 7 ways to get from La Crosse to South Carolina by plane, train (Amtrak), car, taxi, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from La Crosse (LSE) to Greenville–Spartanburg International Airport (GSP)plane plane LSE - GSP
    5h 38m
    $173–666

  2. Fly to Charleston International Airport

    cheapest
    1. Fly from La Crosse (LSE) to Charleston International Airport (CHS)plane plane LSE - CHS
    7h 22m
    $115–483

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    34h 47m
    $509–1,064

  4. Drive 1,153 mi

    1. Drive from La Crosse to Charlestoncar car 1,153 mi
    20h 37m
    $211–304

  5. Fly to Charlotte Douglas International Airport, taxi

    1. Fly from La Crosse (LSE) to Charlotte Douglas International Airport (CLT)plane plane LSE - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    5h 35m
    $218–771

  6. Fly to Columbia

    1. Fly from La Crosse (LSE) to Columbia (CAE)plane plane LSE - CAE
    6h 52m
    $240–1,123

  7. Bus, train, taxi

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Bluffton Transfer Centertaxi taxi
    5. Take the bus from Bluffton Transfer Center to Walmartbus bus 320
    6. Take the taxi from Walmart to Dorchester Village Shopping Center Park & Ridetaxi taxi
    46h 12m

La Crosse (LSE) to Greenville–Spartanburg International Airport (GSP) flights

Calendar21Weekly Planes
Duration6h 23mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to South Carolina.ExpandLaunch map view
  • Distance: 804.6 mi
  • Duration: 5h 38m

What companies run services between La Crosse, WI, USA and South Carolina, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Greenville–Spartanburg International Airport (GSP) 3 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to Charleston via Chicago Union Station, Petersburg Amtrak Station, and Charleston Amtrak Station in around 34h 47m.

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