Rome2Rio

How to get fromLa Crosse to St. Louisby plane, train (Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Find Transport to St. Louis

See all options

There are 7 ways to get from La Crosse to St. Louis by plane, train (Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly La Crosse to Lambert–St. Louis International Airport

    best
    1. Fly from La Crosse (LSE) to Lambert–St. Louis International Airport (STL)plane plane LSE - STL
    5h 27m
    $101–504

  2. Drive  412.7 mi

    cheapest
    1. Drive from La Crosse to St. Louiscar car 412.7 mi
    9h 11m
    $76–109

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 54m
    $135–337

  4. Bus, train

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    12h 42m
    $130–283

  5. Train to Minneapolis–Saint Paul International Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    6h 41m
    $417–1,033

  6. Fly La Crosse to Abraham Lincoln Capital Airport, train

    1. Fly from La Crosse (LSE) to Abraham Lincoln Capital Airport (SPI)plane plane LSE - SPI
    2. Take the train from Springfield to St. Louistrain train
    7h 59m
    $104–437

  7. Bus

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    13h 20m
    $113–172

La Crosse to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration10h 54mAverage Duration
Ticket$135Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from La Crosse to St. Louis.ExpandLaunch map view
  • Distance: 378.4 mi
  • Duration: 5h 27m

What companies run services between La Crosse, WI, USA and St. Louis, MO, USA?

United Airlines and American Airlines fly from La Crosse (LSE) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to St. Louis via Chicago Union Station in around 10h 54m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There