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How to get fromLa Crosse to St. Louisby plane, train (Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from La Crosse to St. Louis by plane, train (Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from La Crosse

    best
    1. Fly from La Crosse (LSE) to Lambert–St. Louis International Airport (STL)plane plane LSE - STL
    5h 28m
    $106–514

  2. Drive 436.3 mi

    cheapest
    1. Drive from La Crosse to St. Louiscar car 436.3 mi
    8h 18m
    $80–115

  3. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 54m
    $181–373

  4. Bus, train

    1. Take the bus from La Crosse to UW-Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to St. Louistrain train
    13h 22m
    $158–308

  5. Train to Minneapolis–Saint Paul International Airport, fly

    1. Take the train from La Crosse Amtrak Station to St. Paul-Minneapolistrain train
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Lambert–St. Louis International Airport (STL)plane plane MSP - STL
    6h 41m
    $427–1,040

  6. Bus

    1. Take the bus from La Crosse to Milwaukee, WI - Amtrakbus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    14h 22m
    $122–192

La Crosse to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration10h 54mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to St. Louis.ExpandLaunch map view
  • Distance: 378.4 mi
  • Duration: 5h 28m

What companies run services between La Crosse, WI, USA and St. Louis, MO, USA?

American Airlines and United Airlines fly from La Crosse (LSE) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a train from La Crosse Amtrak Station to St. Louis via Chicago Union Station in around 10h 54m.

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Train operators
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