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How to get fromLa Crosse to West Lafayetteby plane, train, bus, bus (Greyhound, Flixbus), car, train (Amtrak), or bus (Amtrak)

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There are 8 ways to get from La Crosse to West Lafayette by plane, train, bus, bus (Greyhound, Flixbus), car, train (Amtrak), or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Purdue University Airport

    best
    1. Fly from La Crosse (LSE) to Purdue University Airport (LAF)plane plane LSE - LAF
    4h 26m
    $69–332

  2. Fly to Chicago O'Hare International Airport, bus

    cheapest
    1. Fly from La Crosse (LSE) to Chicago O'Hare International Airport (ORD)plane plane LSE - ORD
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus
    5h 32m
    $68–301

  3. Train, bus

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus FlixBus 2511 / ...
    8h 13m
    $107–219

  4. Bus via Milwaukee

    1. Take the bus from La Crosse to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus
    9h 16m
    $86–136

  5. Drive 400.5 mi

    1. Drive from La Crosse to West Lafayettecar car 400.5 mi
    6h 50m
    $74–106

  6. Fly to Indianapolis, bus

    1. Fly from La Crosse (LSE) to Indianapolis (IND)plane plane LSE - IND
    2. Take the bus from Indianapolis Airport to Purdue Memorial Unionbus bus
    6h 49m
    $121–531

  7. Train (Amtrak)

    1. Take the train from La Crosse Amtrak Station to Chicago Union Stationtrain train Empire Builder / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    9h 9m
    $124–264

  8. Bus

    1. Take the bus from La Crosse to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus
    10h 38m
    $88–158

La Crosse to West Lafayette by train, foot, and bus

Calendar21Weekly Services
Duration8h 13mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

Map of how to get from La Crosse to West Lafayette.ExpandLaunch map view
  • Distance: 334.4 mi
  • Duration: 4h 26m

What companies run services between La Crosse, WI, USA and West Lafayette, IN, USA?

United Airlines flies from La Crosse (LSE) to Purdue University Airport (LAF) 4 times a week. Alternatively, you can take a bus from La Crosse to Lafayette Bus Stop via Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 9h 16m.

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