There are 4 ways to get from La Mesa to Anaheim by bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Line 10 bus, bus
best- Take the bus from University Av & College Av to Old Town Transit Centerbus 10
- Take the bus from San Diego to Anaheim Regional Transportation Intermodal Centerbus FlixBus N2003 / ...
3h 27m$16–30Train (Amtrak)
- Take the train from San Diego Old Town Transportation Center to Fullerton Amtrak Stationtrain Pacific Surfliner
3h 33m$52–99Drive 98.1 mi
- Drive from La Mesa to Anaheimcar 98.1 mi
1h 46m$18–25Bus (Greyhound)
- Take the bus from San Diego to Anaheimbus Tijuana
3h 40m$19–40
La Mesa to Anaheim by bus
Comparing Your Travel Options
The cheapest way to get from La Mesa to Anaheim is to drive which costs $17 - $25 and takes 1h 46m.
The fastest way to get from La Mesa to Anaheim is to drive which takes 1h 46m and costs $17 - $25.
No, there is no direct bus from La Mesa to Anaheim. However, there are services departing from University Av & College Av and arriving at Anaheim Regional Transportation Intermodal Center via San Diego. The journey, including transfers, takes approximately 3h 27m.
No, there is no direct train from La Mesa station to Anaheim station. However, there are services departing from 70th Street Station and arriving at Fullerton Amtrak Station via San Diego Old Town Transportation Center. The journey, including transfers, takes approximately 3h 33m.
The distance between La Mesa and Anaheim is 101 miles. The road distance is 98.7 miles.
The best way to get from La Mesa to Anaheim without a car is to line 10 bus and bus which takes 3h 27m and costs $16 - $30.
It takes approximately 3h 27m to get from La Mesa to Anaheim, including transfers.
La Mesa to Anaheim bus services, operated by San Diego Metro Transit, depart from University Av & College Av station.
La Mesa to Anaheim train services, operated by Amtrak, depart from San Diego Old Town Transportation Center station.
The best way to get from La Mesa to Anaheim is to line 10 bus and bus which takes 3h 27m and costs $16 - $30. Alternatively, you can train, which costs $50 - $100 and takes 3h 33m.
What companies run services between La Mesa, CA, USA and Anaheim, CA, USA?
You can take a bus from University Av & College Av to Anaheim Regional Transportation Intermodal Center via Old Town Transit Center and San Diego in around 3h 27m. Alternatively, Amtrak operates a train from San Diego Old Town Transportation Center to Fullerton Amtrak Station hourly. Tickets cost $50–85 and the journey takes 2h 10m.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from San Diego Old Town Transportation Center to Fullerton Amtrak Station
- Ave. Duration
- 2h 10m
- Frequency
- Hourly
- Estimated price
- $50–85
- Website
- Amtrak
- Phone
- +1 619-557-4555
- Website
- MTS
Bus from University Av & College Av to Old Town Transit Center
- Ave. Duration
- 52 min
- Frequency
- Every 30 minutes
- Estimated price
- $2–5
- Website
- MTS
- Schedules at
- MTS Schedules
- One Way - Adult/Youth
- $2–5
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from San Diego to Anaheim Regional Transportation Intermodal Center
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- $14–22
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from San Diego to Anaheim Regional Transportation Intermodal Center
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $16–25
- Website
- Greyhound
- Phone
- +1-800-231-2222
- [email protected]
- Website
- Greyhound Mexico
Bus from San Diego to Anaheim
- Ave. Duration
- 2h 10m
- Frequency
- Twice daily
- Estimated price
- $17–27
- Schedules at
- Greyhound Mexico
Want to know more about travelling around United States
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Booking & Getting There
La Mesa to Anaheim bus services, operated by San Diego Metro Transit, arrive at Old Town Transit Center station.
La Mesa to Anaheim train services, operated by Amtrak, arrive at Fullerton Amtrak Station.
Yes, the driving distance between La Mesa to Anaheim is 99 miles. It takes approximately 1h 46m to drive from La Mesa to Anaheim.
There are 1332+ hotels available in Anaheim.

















