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How to get fromLa Mesa to San Franciscoby tram, plane, bus (Greyhound), train (Amtrak), car, subway, train, shuttle, or bus

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There are 8 ways to get from La Mesa to San Francisco by tram, plane, bus (Greyhound), train (Amtrak), car, subway, train, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Tram, fly to San Francisco International Airport

    best
    1. Take the tram from Grossmont Station to Old Town Stationtram tram
    2. Fly from San Diego International Airport (SAN) to San Francisco International Airport (SFO)plane plane SAN - SFO
    3h 56m
    $72–257

  2. Tram, fly to Oakland International Airport, BART

    cheapest
    1. Take the tram from Grossmont Station to Old Town Stationtram tram
    2. Fly from San Diego International Airport (SAN) to Oakland International Airport (OAK)plane plane SAN - OAK
    3. Take the subway from Coliseum to Powell Streetsubway subway
    4h 10m
    $68–293

  3. Bus (Greyhound)

    1. Take the bus from San Diego Greyhound Bus Stop to Oaklandbus bus Greyhound US0831
    12h 37m
    $79–168

  4. Train (Amtrak)

    1. Take the train from San Diego Old Town Transportation Center to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to Oaklandtrain train Coast Starlight
    17h
    $180–413

  5. Drive 504.2 mi

    1. Drive from La Mesa to San Franciscocar car 504.2 mi
    8h 28m
    $92–133

  6. Fly to Norman Y. Mineta San José International Airport, Caltrain

    1. Fly from San Diego International Airport (SAN) to Norman Y. Mineta San José International Airport (SJC)plane plane SAN - SJC
    2. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    5h 12m
    $84–510

  7. Fly to Sonoma County Airport, shuttle

    1. Fly from San Diego International Airport (SAN) to Sonoma County Airport (STS)plane plane SAN - STS
    2. Take a shuttle bus from Santa Rosa Airport to San Francisco Pier 27shuttle bus
    5h 57m
    $168–315

  8. Bus, BART

    1. Take the bus from San Ysidro to San Jose - King Rdbus bus San Ysidro
    2. Take the subway from Berryessa / North San Jose to Civic Center / UN Plazasubway subway Green-S
    14h 24m
    $104–165

La Mesa to San Francisco by tram, bus, and subway (Greyhound)

Calendar7Weekly Services
Duration12h 37mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from La Mesa to San Francisco.ExpandLaunch map view
  • Distance: 477.7 mi
  • Duration: 3h 56m

What companies run services between La Mesa, CA, USA and San Francisco, CA, USA?

Greyhound USA operates a bus from San Diego Greyhound Bus Stop to Oakland once daily. Tickets cost $75–150 and the journey takes 10h 55m. Alternatively, you can take a vehicle from 70th Street Station to Civic Center / UN Plaza via Old Town Station, San Diego Old Town Transportation Center, Los Angeles, Oakland, and Lake Merritt in around 17h.

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