Rome2Rio

How to get fromLa Mesa to San Luis Obispoby tram, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Find Transport to San Luis Obispo

See all options

There are 6 ways to get from La Mesa to San Luis Obispo by tram, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Tram, fly to San Luis Obispo County Regional Airport

    best
    1. Take the tram from Grossmont Station to Old Town Stationtram tram
    2. Fly from San Diego International Airport (SAN) to San Luis Obispo County Regional Airport (SBP)plane plane SAN - SBP
    4h 21m
    $174–367

  2. Bus

    cheapest
    1. Take the bus from San Diego Greyhound Bus Stop to Los Angeles Union Stationbus bus Greyhound US0831
    2. Take the bus from Los Angeles Union Station to San Luis Obispo Railroad Museumbus bus FlixBus 2005
    9h 27m
    $50–90

  3. Train (Amtrak)

    1. Take the train from San Diego Old Town Transportation Center to San Luis Obispotrain train Pacific Surfliner
    9h 55m
    $102–244

  4. Drive 308.4 mi

    1. Drive from La Mesa to San Luis Obispocar car 308.4 mi
    5h 36m
    $57–82

  5. Fly to Santa Barbara Municipal Airport, bus

    1. Fly from San Diego International Airport (SAN) to Santa Barbara Municipal Airport (SBA)plane plane SAN - SBA
    2. Take the bus from Uc Santa Barbara Amtrak Bus Stop to San Luis Obispobus bus
    6h 37m
    $108–287

  6. Bus via Santa Maria Airport (SMX)

    1. Take the bus from San Diego to LAX Terminal 3 Shared Rides Stopbus bus
    2. Take the bus from Los Angeles Airport, CA to Santa Maria Airport, CAbus bus
    3. Take the bus from Santa Maria Transit Center to Government Centerbus bus 10N
    12h 2m
    $145–240

La Mesa to San Luis Obispo by bus

Calendar4Weekly Buses
Duration9h 27mAverage Duration
Ticket$50Cheapest Price
See schedules

Questions & Answers

Map of how to get from La Mesa to San Luis Obispo.ExpandLaunch map view
  • Distance: 283.3 mi
  • Duration: 4h 21m

What companies run services between La Mesa, CA, USA and San Luis Obispo, CA, USA?

You can take a bus from University Av & College Av to San Luis Obispo Railroad Museum via Old Town Transit Center, San Diego Greyhound Bus Stop, and Los Angeles Union Station in around 9h 27m. Alternatively, Amtrak operates a train from San Diego Old Town Transportation Center to San Luis Obispo twice daily. Tickets cost $100–230 and the journey takes 8h 27m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers