There are 4 ways to get from La Mesa to Simi Valley by train (Amtrak), tram, bus, subway, car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from San Diego Old Town Transportation Center to Moorpark Amtraktrain Pacific Surfliner
6h 59m$43–118Bus
cheapest- Take the bus from San Diego Greyhound Bus Stop to Los Angeles Union Stationbus Greyhound US0831 / ...
- Take the bus from Hill St & 5th St to Chatsworth Metrolink Stationbus 419
8h 59m$24–43Tram, bus, subway, line 10 bus
- Take the tram from La Mesa Blvd Station to 12th & Imperial Stationtram
- Take the bus from San Diego to Los Angeles Union Stationbus
- Take the subway from Union Station - Metro B & D Lines to North Hollywood Stationsubway
- Take the bus from North Hollywood Station to Chatsworth Stationbus
- Take the bus from Metrolink Chatsworth to Cochran Street and First Streetbus 10
8h 9m$27–59Drive 164.4 mi
- Drive from La Mesa to Simi Valleycar 164.4 mi
2h 53m$30–44
La Mesa to Simi Valley by tram, train, and bus (Amtrak)
Comparing Your Travel Options
The cheapest way to get from La Mesa to Simi Valley is to bus which costs $24 - $45 and takes 8h 59m.
The fastest way to get from La Mesa to Simi Valley is to drive which takes 2h 53m and costs $30 - $45.
No, there is no direct bus from La Mesa to Simi Valley. However, there are services departing from University Av & College Av and arriving at Cochran Street and First Street via San Diego Greyhound Bus Stop, Hill St & 5th St and Metrolink Chatsworth. The journey, including transfers, takes approximately 8h 59m.
No, there is no direct train from La Mesa station to Simi Valley. However, there are services departing from 70th Street Station and arriving at Moorpark Amtrak via San Diego Old Town Transportation Center. The journey, including transfers, takes approximately 6h 59m.
The distance between La Mesa and Simi Valley is 191 miles. The road distance is 165.3 miles.
The best way to get from La Mesa to Simi Valley without a car is to train which takes 6h 59m and costs $40 - $120.
It takes approximately 6h 59m to get from La Mesa to Simi Valley, including transfers.
La Mesa to Simi Valley bus services, operated by Greyhound USA, depart from San Diego Greyhound Bus Stop station.
La Mesa to Simi Valley train services, operated by Amtrak, depart from San Diego Old Town Transportation Center station.
The best way to get from La Mesa to Simi Valley is to train which takes 6h 59m and costs $40 - $120. Alternatively, you can bus, which costs $24 - $45 and takes 8h 59m.
What companies run services between La Mesa, CA, USA and Simi Valley, CA, USA?
Amtrak operates a train from San Diego Old Town Transportation Center to Moorpark Amtrak 5 times a day. Tickets cost $40–100 and the journey takes 4h 14m. Alternatively, you can take a bus from University Av & College Av to Cochran Street and First Street via Old Town Transit Center, San Diego Greyhound Bus Stop, Los Angeles Union Station, Union Station - Metro B & D Lines, Pershing Square Station, Hill St & 5th St, Chatsworth Metrolink Station, and Metrolink Chatsworth in around 8h 59m.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from San Diego Old Town Transportation Center to Moorpark Amtrak
- Ave. Duration
- 4h 14m
- Frequency
- 5 times a day
- Estimated price
- $40–100
- Website
- Amtrak
- Phone
- +1-800-231-2222
- [email protected]
- Website
- Greyhound Mexico
Bus from San Diego to Los Angeles Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $22–40
- Schedules at
- Greyhound Mexico
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
La Mesa to Simi Valley bus services, operated by Greyhound USA, arrive at Los Angeles Union Station.
La Mesa to Simi Valley train services, operated by Amtrak, arrive at Moorpark Amtrak station.
Yes, the driving distance between La Mesa to Simi Valley is 165 miles. It takes approximately 2h 53m to drive from La Mesa to Simi Valley.
There are 184+ hotels available in Simi Valley.











