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How to get fromLa Serena to Santa Cruzby plane, train, bus, or car

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There are 7 ways to get from La Serena to Santa Cruz by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, train, bus

    best
    1. Fly from La Florida Airport (LSC) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane LSC - SCL
    2. Take the train from Estacion Central Alameda to San Fernandotrain train
    3. Take the bus from Terminal Rodoviario de San Fernando to Terminal de Buses Santa Cruzbus bus
    5h 21m
    $24–96

  2. Bus

    cheapest
    1. Take the bus from Terminal de buses La Serena to Terminal San Borjabus bus Santiago / ...
    2. Take the bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruzbus bus Santiago
    9h 37m
    $13–87

  3. Drive 622.1 km

    1. Drive from La Serena to Santa Cruzcar car 622.1 km
    7h 27m
    $77–111

  4. Bus via Hospital

    1. Take the bus from Terminal de buses La Serena to Terminal Alameda - Turbusbus bus Santiago / ...
    2. Take the bus from Terminal Sur de Santiago to Hospitalbus bus Santiago
    9h 41m
    $17–84

  5. Bus, train

    1. Take the bus from Terminal de buses La Serena to Santiagobus bus
    2. Take the train from Estacion Central Alameda to San Fernandotrain train
    3. Take the bus from Terminal Rodoviario de San Fernando to Terminal de Buses Santa Cruzbus bus
    9h 59m
    $55–99

  6. Bus via Peralillo

    1. Take the bus from Terminal de buses La Serena to Terminal San Borjabus bus Santiago
    2. Take the bus from Terminal Sur de Santiago to Peralillobus bus Santiago / ...
    11h
    $23–61

  7. Bus, train via Terminal de Buses de Coquimbo

    1. Take the bus from Terminal de Buses de Coquimbo to Terminal Alameda - Turbusbus bus
    2. Take the train from Estacion Central Alameda to San Fernandotrain train
    3. Take the bus from Terminal Rodoviario de San Fernando to Hospitalbus bus
    11h 15m
    $19–155

La Florida Airport (LSC) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

Calendar52Weekly Planes
Duration58 minAverage Duration
Ticket$17Cheapest Price
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Questions & Answers

Map of how to get from La Serena to Santa Cruz.ExpandLaunch map view
  • Distance: 582.9 km
  • Duration: 5h 21m

What companies run services between La Serena, Chile and Santa Cruz, O'Higgins, Chile?

You can take a bus from Terminal de buses La Serena to Terminal de Buses Santa Cruz via Terminal San Borja and Terminal Sur de Santiago in around 9h 37m.

Airlines
Train operators
Bus operators

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