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How to get fromLa Serena to Santa Cruz de la Sierraby plane, bus (Flixbus), car, or bus

Find Transport to Santa Cruz de la Sierra

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There are 5 ways to get from La Serena to Santa Cruz de la Sierra by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from La Florida Airport (LSC) to Viru Viru International Airport (VVI)plane plane LSC - VVI
    6h 50m
    $315–451

  2. Bus via Antofagasta

    cheapest
    1. Take the bus from Terminal de buses La Serena to Terminal de Buses Cardenal Carlos Oviedo Cavadabus bus Calama / ...
    2. Take the bus from Terminal de Buses Cardenal Carlos Oviedo Cavada to Santa Cruzbus bus Santa Cruz
    34h 31m
    $61–116

  3. Bus

    1. Take the bus from Terminal de buses La Serena to Rodovario de Iquiquebus bus Santiago- Iquique / ...
    2. Take the bus from Iquique to Santa Cruzbus bus Santa Cruz
    32h 6m

  4. Drive 2,204.4 km

    1. Drive from La Serena to Santa Cruz de la Sierracar car 2,204.4 km
    30h 16m
    $272–393

  5. Bus #2

    1. Take the bus from Terminal de buses La Serena to Terminal Mendozabus bus La Serena
    2. Take the bus from Terminal Mendoza to Santa Cruzbus bus
    45h 15m
    $138–241

La Florida Airport (LSC) to Viru Viru International Airport (VVI) flights

Calendar3Weekly Planes
Duration9h 36mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from La Serena to Santa Cruz de la Sierra.ExpandLaunch map view
  • Distance: 1,610.5 km
  • Duration: 6h 50m

What companies run services between La Serena, Chile and Santa Cruz de la Sierra, Bolivia?

LATAM Chile, Boliviana de Aviación, and Sky Airline fly from La Florida Airport (LSC) to Viru Viru International Airport (VVI) 3 times a week. Alternatively, you can take a bus from Terminal de buses La Serena to Santa Cruz via Iquique in around 32h 6m.

Airlines
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