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How to get fromLa Serena to Santiagoby plane, bus (Flixbus), car, or bus

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There are 5 ways to get from La Serena to Santiago by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from La Florida Airport (LSC) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane LSC - SCL
    1h 17m
    $23–80
  2. Bus

    cheapest
    1. Take the bus from Terminal de buses La Serena to Santiagobus bus FlixBus CL043 / ...
    6h
    $8–75
  3. Drive 473.4 km

    1. Drive from La Serena to Santiagocar car 473.4 km
    4h 52m
    $59–85
  4. Bus via Santiago (Flixbus)

    1. Take the bus from Terminal de Buses de Coquimbo to Santiagobus bus FlixBus CL040
    6h 41m
    $51–155
  5. Bus via Quilimarí

    1. Take the bus from Terminal de buses La Serena to Pichidangui - Crucebus bus Santiago
    2. Take the bus from Pichidangui - Cruce to Terminal San Borjabus bus Santiago
    6h 55m
    $12–31

La Serena to Santiago by bus

Calendar771Weekly Buses
Duration6hAverage Duration
Ticket$8Cheapest Price
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Questions & Answers

What companies run services between La Serena, Chile and Santiago, Chile?

Sky Airline, JetSMART, and LATAM Chile fly from La Florida Airport (LSC) to Comodoro Arturo Merino Benítez International Airport (SCL) every 4 hours. Alternatively, Flixbus Chile operates a bus from Terminal de buses La Serena to Santiago hourly. Tickets cost $50–90 and the journey takes 6h. 11 other operators also service this route.

Airlines
Bus operators

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