There are 5 ways to get from La Serena to Santiago by plane, bus (Flixbus), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from La Florida Airport (LSC) to Comodoro Arturo Merino Benítez International Airport (SCL)plane LSC - SCL
1h 17m$23–80Bus
cheapest- Take the bus from Terminal de buses La Serena to Santiagobus FlixBus CL043 / ...
6h$8–75Drive 473.4 km
- Drive from La Serena to Santiagocar 473.4 km
4h 52m$59–85Bus via Santiago (Flixbus)
- Take the bus from Terminal de Buses de Coquimbo to Santiagobus FlixBus CL040
6h 41m$51–155Bus via Quilimarí
- Take the bus from Terminal de buses La Serena to Pichidangui - Crucebus Santiago
- Take the bus from Pichidangui - Cruce to Terminal San Borjabus Santiago
6h 55m$12–31
La Serena to Santiago by bus
Questions & Answers
The cheapest way to get from La Serena to Santiago is to bus via Quilimarí which costs $12 - $35 and takes 6h 55m.
The fastest way to get from La Serena to Santiago is to fly which takes 1h 17m and costs $22 - $85.
Yes, there is a direct bus departing from Terminal de buses La Serena and arriving at Santiago. Services depart every 30 minutes, and operate every day. The journey takes approximately 6h.
The distance between La Serena and Santiago is 401 km. The road distance is 473.4 km.
The best way to get from La Serena to Santiago without a car is to bus which takes 6h and costs $8 - $75.
It takes approximately 1h 17m to get from La Serena to Santiago, including transfers.
La Serena to Santiago bus services, operated by Flixbus Chile, depart from Terminal de buses La Serena station.
The best way to get from La Serena to Santiago is to fly which takes 1h 17m and costs $22 - $85. Alternatively, you can bus, which costs $8 - $75 and takes 6h.
La Serena to Santiago bus services, operated by Flixbus Chile, arrive at Santiago station.
Yes, the driving distance between La Serena to Santiago is 473 km. It takes approximately 4h 52m to drive from La Serena to Santiago.
What companies run services between La Serena, Chile and Santiago, Chile?
Sky Airline, JetSMART, and LATAM Chile fly from La Florida Airport (LSC) to Comodoro Arturo Merino Benítez International Airport (SCL) every 4 hours. Alternatively, Flixbus Chile operates a bus from Terminal de buses La Serena to Santiago hourly. Tickets cost $50–90 and the journey takes 6h. 11 other operators also service this route.
- Website
- latam.com
Flights from La Florida Airport to Comodoro Arturo Merino Benítez International Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- $40–95
- Website
- skyairline.com
Flights from La Florida Airport to Comodoro Arturo Merino Benítez International Airport
- Ave. Duration
- 1h 1m
- When
- Thursday to Wednesday
- Estimated price
- $19–75
- Website
- jetsmart.com
Flights from La Florida Airport to Comodoro Arturo Merino Benítez International Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- $28–75
- Website
- Flixbus Chile
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h
- Frequency
- Hourly
- Estimated price
- $50–90
- Schedules at
- Flixbus Chile
Bus from Terminal de Buses de Coquimbo to Santiago
- Ave. Duration
- 5h 10m
- Frequency
- Every 4 hours
- Estimated price
- $50–85
- Schedules at
- Flixbus Chile
- Phone
- +56 22 3813 550
- [email protected]
- Website
- plusschile.cl
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 20m
- Frequency
- Twice daily
- Estimated price
- $14–27
- Book at
- Recorrido Pluss Chile
- Semi Cama
- $15–19
- Cama
- $21–27
- Phone
- +56 22 683 8528
- [email protected]
- Website
- Andimar
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 10m
- Frequency
- Hourly
- Estimated price
- $12–28
- Schedules at
- Andimar
- Semi Cama
- $12–16
- Cama
- $17–28
Bus from Terminal de buses La Serena to Pichidangui - Cruce
- Ave. Duration
- 3h 20m
- Frequency
- Hourly
- Estimated price
- $6–16
- Schedules at
- Andimar
- Semi Cama
- $6–11
- Cama
- $8–16
Bus from Pichidangui - Cruce to Terminal San Borja
- Ave. Duration
- 2h 50m
- Frequency
- Hourly
- Estimated price
- $6–16
- Schedules at
- Andimar
- Semi Cama
- $6–11
- Cama
- $9–16
- Phone
- +56 600 600 0018
- [email protected]
- Website
- pullmanbus.cl
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 30m
- Frequency
- Every 2 hours
- Estimated price
- $23–40
- Schedules at
- pullmanbus.cl
- Book at
- pullmanbus.cl
- Salón Cama
- $25–40
- Phone
- +56 51 221 5300
- [email protected]
- Website
- Buses Romani
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 30m
- Frequency
- Hourly
- Estimated price
- $9–27
- Schedules at
- Buses Romani
- Semi
- $9–11
- Salon
- $22–27
- Phone
- +56 22 822 7500
- [email protected]
- Website
- turbus.cl
Bus from Terminal de buses La Serena to Santiago
- Semi Cama
- $17–25
- Cama
- $25–35
- Premium
- $60–75
- [email protected]
- Website
- Pullman San Andres
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 7h
- Frequency
- Every 4 hours
- Estimated price
- $35–60
- Schedules at
- Pullman San Andres
- Semi Cama
- $35–50
- Cama
- $40–60
- [email protected]
- Website
- ciktur.cl
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 45m
- Frequency
- 4 times a day
- Estimated price
- $29–45
- Schedules at
- kupos.cl
- Cama
- $35–45
- Semi Cama
- $29–40
- Phone
- +56 57 226 9210
- [email protected]
- Website
- Ramos Cholele
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 27m
- Frequency
- Twice daily
- Estimated price
- $14–48
- Schedules at
- Ramos Cholele
- Semi cama
- $14–19
- Salón cama
- $44–48
- Phone
- +56 512 669924
- [email protected]
- Website
- kupos.cl
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h
- Frequency
- Once daily
- Estimated price
- $19–28
- Schedules at
- busesserenamar.cl
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 20m
- Frequency
- Once daily
- Estimated price
- $17
- Schedules at
- Buses Paravias
- Phone
- +56 2 3304 8632 / 2 2596 1100
- [email protected]
- Website
- Expreso Norte
Bus from Terminal de buses La Serena to Santiago
- Ave. Duration
- 6h 27m
- Frequency
- Once daily
- Estimated price
- $8–25
- Schedules at
- Expreso Norte
Bus from Pichidangui - Cruce to Terminal San Borja
- Ave. Duration
- 2h 30m
- Frequency
- 3 times a day
- Estimated price
- $6–10
- Schedules at
- Expreso Norte
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