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How to get fromLady Lake to Florida Keysby car, train, bus, shuttle, plane, bus (Greyhound), or taxi

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There are 12 ways to get from Lady Lake to Florida Keys by car, train, bus, shuttle, plane, bus (Greyhound), or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Lady Lake to Orlandocar car
    2. Take the train from Orlando to Miamitrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    11h 6m
    $92–252

  2. Drive  399.2 mi

    cheapest
    1. Drive from Lady Lake to Florida Keyscar car 399.2 mi
    8h 7m
    $73–106

  3. Shuttle to Orlando, fly to Key West International Airport

    1. Take a shuttle bus from Lake Sumter Depot to MCO Airport - Terminal Ashuttle bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    7h 2m
    $192–817

  4. Shuttle, bus

    1. Take a shuttle bus from Spanish Springs to MCO Airport - Terminal Ashuttle bus
    2. Take the bus from Orlando to Miami Airport Stationbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    14h
    $231–310

  5. Bus

    1. Take the bus from Ocala, FL to Miami Airportbus bus Tallahassee
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    12h 40m
    $155–255

  6. Bus, train

    1. Take the bus from Ocala, FL to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    13h 11m
    $140–236

  7. Bus, train via Lakeland

    1. Take the bus from The Villages-Lady Lake Amtrak Bus Stop to Lakelandbus bus
    2. Take the train from Lakeland to Fort Lauderdale Amtrak Stationtrain train
    3. Take the train from Fort Lauderdale Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    15h 14m
    $112–216

  8. Shuttle to Tampa, fly to Key West International Airport

    1. Take a shuttle bus from Lake Sumter Depot to Tampa International Airport - Red Terminalshuttle bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    7h 49m
    $197–422

  9. Taxi to Orlando Sanford, fly to Key West International Airport

    1. Take the taxi from Lady Lake to Orlando-Sanford-Airport-SFBtaxi taxi
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    5h 22m
    $230–483

  10. Shuttle to Orlando, fly to Miami International Airport, shuttle

    1. Take a shuttle bus from Lake Sumter Depot to MCO Airport - Terminal Ashuttle bus
    2. Fly from Orlando (MCO) to Miami International Airport (MIA)plane plane MCO - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 26m
    $802–1,357

  11. Shuttle to Orlando, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take a shuttle bus from Lake Sumter Depot to MCO Airport - Terminal Ashuttle bus
    2. Fly from Orlando (MCO) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MCO - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 53m
    $482–927

  12. Shuttle to Saint Petersburg–Clearwater International Airport, fly to Key West International Airport

    1. Take a shuttle bus from Lake Sumter Depot to Tampa International Airport - Red Terminalshuttle bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    9h 48m
    $178–428

Orlando (MCO) to Key West International Airport (EYW) flights

Calendar30Weekly Planes
Duration3h 1mAverage Duration
Ticket$34Cheapest Price
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Questions & Answers

Map of how to get from Lady Lake to Florida Keys.ExpandLaunch map view
  • Distance: 442.5 mi
  • Duration: 11h 6m

What companies run services between Lady Lake, FL, USA and Florida Keys, FL, USA?

You can take a vehicle from Lady Lake to Florida Keys via Ocala, FL, Miami Airport, Miami International Airport, Miami, Airport Intermodal Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 12h 40m.

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