Rome2Rio

How to get fromLady Lake to Florida Keysby car, train, bus, shuttle, plane, bus (Greyhound), or taxi

Find Transport to Florida Keys

See all options

There are 13 ways to get from Lady Lake to Florida Keys by car, train, bus, shuttle, plane, bus (Greyhound), or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Lady Lake to Orlandocar car
    2. Take the train from Orlando to Miamitrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    11h 6m
    $92–252

  2. Drive 399.2 mi

    cheapest
    1. Drive from Lady Lake to Florida Keyscar car 399.2 mi
    8h 7m
    $73–106

  3. Shuttle to Tampa, fly to Key West International Airport

    1. Take a shuttle bus from Lake Sumter Depot to Tampa International Airport - Red Terminalshuttle bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    7h 53m
    $217–602

  4. Shuttle, bus

    1. Take a shuttle bus from Spanish Springs to MCO Airport - Terminal Ashuttle bus
    2. Take the bus from Orlando to Miami Airport Stationbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    14h
    $231–310

  5. Bus

    1. Take the bus from Ocala, FL to Miami Airportbus bus Tallahassee
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    12h 40m
    $160–255

  6. Bus, train

    1. Take the bus from Ocala, FL to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    13h 11m
    $145–236

  7. Bus, train via Lakeland

    1. Take the bus from The Villages-Lady Lake Amtrak Bus Stop to Lakelandbus bus
    2. Take the train from Lakeland to Fort Lauderdale Amtrak Stationtrain train
    3. Take the train from Fort Lauderdale Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    15h 14m
    $118–226

  8. Shuttle to Orlando, fly to Key West International Airport

    1. Take a shuttle bus from Lake Sumter Depot to MCO Airport - Terminal Ashuttle bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    6h 54m
    $192–817

  9. Taxi to Orlando Sanford, fly to Key West International Airport

    1. Take the taxi from Lady Lake to Orlando-Sanford-Airport-SFBtaxi taxi
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    5h 22m
    $230–483

  10. Shuttle to Orlando, fly to Miami International Airport, shuttle

    1. Take a shuttle bus from Lake Sumter Depot to MCO Airport - Terminal Ashuttle bus
    2. Fly from Orlando (MCO) to Miami International Airport (MIA)plane plane MCO - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 27m
    $752–1,357

  11. Shuttle to Orlando, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take a shuttle bus from Lake Sumter Depot to MCO Airport - Terminal Ashuttle bus
    2. Fly from Orlando (MCO) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MCO - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 52m
    $482–877

  12. Shuttle to Saint Petersburg–Clearwater International Airport, fly to Key West International Airport

    1. Take a shuttle bus from Lake Sumter Depot to Tampa International Airport - Red Terminalshuttle bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    9h 48m
    $178–428

  13. Shuttle to Tampa, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take a shuttle bus from Lake Sumter Depot to Tampa International Airport - Red Terminalshuttle bus
    2. Fly from Tampa (TPA) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TPA - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 48m
    $337–772

Tampa (TPA) to Key West International Airport (EYW) flights

Calendar8Weekly Planes
Duration1h 18mAverage Duration
Ticket$78Cheapest Price
See schedules

Questions & Answers

Map of how to get from Lady Lake to Florida Keys.ExpandLaunch map view
  • Distance: 442.5 mi
  • Duration: 11h 6m

What companies run services between Lady Lake, FL, USA and Florida Keys, FL, USA?

You can take a vehicle from Lady Lake to Florida Keys via Ocala, FL, Miami Airport, Miami International Airport, Miami, Airport Intermodal Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 12h 40m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound