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How to get fromLafayette to Knoxvilleby shuttle, plane, bus (Amtrak, Flixbus), train, bus, car, or bus (Amtrak, Greyhound)

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There are 10 ways to get from Lafayette to Knoxville by shuttle, plane, bus (Amtrak, Flixbus), train, bus, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Indianapolis, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Holiday Inn City Centre to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS)plane plane IND - TYS
    5h 52m
    $190–903

  2. Drive 408.4 mi

    cheapest
    1. Drive from Lafayette to Knoxvillecar car 408.4 mi
    7h 7m
    $75–108

  3. Bus via Gary

    1. Take the bus from Lafayette Amtrak Station to Gary, INbus bus
    2. Take the bus from Gary Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    33h 16m
    $332–516

  4. Train, bus via Farragut

    1. Take the train from Lafayette Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h
    $503–920

  5. Fly Purdue University Airport to Mcghee Tyson Airport

    1. Fly from Purdue University Airport (LAF) to Mcghee Tyson Airport (TYS)plane plane LAF - TYS
    6h 3m
    $186–821

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    5h 33m
    $221–791

  7. Shuttle to Indianapolis, fly to Nashville, drive

    1. Take a shuttle bus from Holiday Inn City Centre to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Nashville (BNA)plane plane IND - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 24m
    $355–1,183

  8. Train to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    7h 1m
    $228–957

  9. Bus

    1. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    36h 47m
    $317–525

  10. Train, bus

    1. Take the train from Lafayette Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    38h 4m
    $458–830

Indianapolis (IND) to Mcghee Tyson Airport (TYS) flights

Calendar144Weekly Planes
Duration4h 43mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from Lafayette to Knoxville.ExpandLaunch map view
  • Distance: 379.1 mi
  • Duration: 5h 52m

What companies run services between Lafayette, IN, USA and Knoxville, TN, USA?

You can take a bus from Lafayette Amtrak Station to Knoxville via Gary, IN, Gary Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 33h 16m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Mcghee Tyson Airport (TYS) 3 times a day.

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