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How to get fromLafayette to La Crosseby bus, train, car, plane, train (Amtrak), or shuttle

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There are 7 ways to get from Lafayette to La Crosse by bus, train, car, plane, train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train (Amtrak)

    best
    1. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    8h 19m
    $109–234

  2. Fly from Purdue University Airport

    cheapest
    1. Fly from Purdue University Airport (LAF) to La Crosse (LSE)plane plane LAF - LSE
    6h 2m
    $70–344

  3. Bus

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    9h 7m
    $114–176

  4. Drive 402.8 mi

    1. Drive from Lafayette to La Crossecar car 402.8 mi
    6h 50m
    $74–107

  5. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    9h 23m
    $123–269

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane plane ORD - LSE
    5h 5m
    $115–374

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from Holiday Inn City Centre to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to La Crosse (LSE)plane plane IND - LSE
    6h 37m
    $94–446

Lafayette to La Crosse by bus and train (Amtrak)

Calendar14Weekly Services
Duration8h 19mAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from Lafayette to La Crosse.ExpandLaunch map view
  • Distance: 401.5 mi
  • Duration: 8h 19m

What companies run services between Lafayette, IN, USA and La Crosse, WI, USA?

You can take a bus from Purdue Memorial Union to La Crosse via Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, and Madison in around 9h 7m. Alternatively, United Airlines and American Airlines fly from Purdue University Airport (LAF) to La Crosse (LSE) twice daily.

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