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How to get fromLafayette to Mayo Clinicby bus, train, car, plane, bus (Amtrak, Flixbus, Greyhound), or shuttle

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There are 9 ways to get from Lafayette to Mayo Clinic by bus, train, car, plane, bus (Amtrak, Flixbus, Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    11h 15m
    $129–196

  2. Fly Purdue University Airport to Rochester

    cheapest
    1. Fly from Purdue University Airport (LAF) to Rochester (RST)plane plane LAF - RST
    7h 42m
    $52–371

  3. Train, bus

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    14h 28m
    $186–389

  4. Drive 467.9 mi

    1. Drive from Lafayette to Mayo Cliniccar car 467.9 mi
    7h 53m
    $86–124

  5. Bus via Chicago

    1. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus
    2. Take the bus from Chicago Bus Station to Madisonbus bus
    3. Take the bus from Madison to Rochesterbus bus
    12h 42m
    $99–169

  6. Train, bus via Madison

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 30m
    $113–209

  7. Shuttle to Indianapolis, fly to Rochester

    1. Take a shuttle bus from Holiday Inn City Centre to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Rochester (RST)plane plane IND - RST
    7h 29m
    $81–483

  8. Bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    6h 9m
    $97–401

  9. Shuttle to Indianapolis, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take a shuttle bus from Holiday Inn City Centre to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 6m
    $567–1,185

Lafayette to Mayo Clinic by train, bus, and foot

Calendar3Weekly Services
Duration14h 28mAverage Duration
Ticket$186Cheapest Price
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Questions & Answers

Map of how to get from Lafayette to Mayo Clinic.ExpandLaunch map view
  • Distance: 473.9 mi
  • Duration: 11h 15m

What companies run services between Lafayette, IN, USA and Mayo Clinic, MN, USA?

You can take a bus from Purdue Memorial Union to Mayo Clinic via Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 11h 15m. Alternatively, United Airlines and American Airlines fly from Purdue University Airport (LAF) to Rochester (RST) 3 times a day.

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