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How to get fromLafayette to St. Louisby train, bus, train (Amtrak), car, plane, bus (Amtrak, Greyhound), bus (Greyhound), or shuttle

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There are 9 ways to get from Lafayette to St. Louis by train, bus, train (Amtrak), car, plane, bus (Amtrak, Greyhound), bus (Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Lafayette Amtrak Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    6h 48m
    $59–119

  2. Drive 253.3 mi

    cheapest
    1. Drive from Lafayette to St. Louiscar car 253.3 mi
    4h 58m
    $47–67

  3. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 10m
    $129–269

  4. Fly from Purdue University Airport

    1. Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane plane LAF - STL
    6h 11m
    $79–464

  5. Bus

    1. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus Chicago
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    7h 15m
    $49–112

  6. Bus via Indianapolis Airport (IND)

    1. Take the bus from Courtyard Lafayette to Indianapolis Airportbus bus Purdue
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    7h 25m
    $64–106

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from Holiday Inn City Centre to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane plane IND - STL
    6h 18m
    $113–636

  8. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 27m
    $329–774

  9. Train to Chicago Midway International Airport, fly

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    7h 9m
    $122–640

Lafayette to St. Louis by train and bus

Calendar3Weekly Services
Duration6h 48mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Lafayette to St. Louis.ExpandLaunch map view
  • Distance: 317 mi
  • Duration: 6h 48m

What companies run services between Lafayette, IN, USA and St. Louis, MO, USA?

You can take a train from Lafayette Amtrak Station to St. Louis via Chicago Union Station in around 9h 10m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL) once daily.

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