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How to get fromLafayette to St. Louisby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 6 ways to get from Lafayette to St. Louis by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Lafayette Regional Airport

    best
    1. Fly from Lafayette Regional Airport (LFT) to Lambert–St. Louis International Airport (STL)plane plane LFT - STL
    5h 13m
    $134–616

  2. Bus

    cheapest
    1. Take the bus from Lafayette to Baton Rouge Bus Stationbus bus FlixBus 2211 / ...
    2. Take the bus from Baton Rouge Bus Station to St Louis Bus Stationbus bus Greyhound US1173
    18h 45m
    $119–245

  3. Bus, train

    1. Take the bus from Lafayette to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    3. Take the bus from Carbondale to St. Louisbus bus
    19h 48m
    $237–506

  4. Drive 708.3 mi

    1. Drive from Lafayette to St. Louiscar car 708.3 mi
    11h 52m
    $130–187

  5. Bus to Louis Armstrong New Orleans International Airport, fly

    1. Take the bus from Lafayette Transit System to New Orleans International Airportbus bus
    2. Fly from Louis Armstrong New Orleans International Airport (MSY) to Lambert–St. Louis International Airport (STL)plane plane MSY - STL
    7h 11m
    $425–944

  6. Bus to Lake Charles Regional Airport, fly

    1. Take the bus from Lafayette to Lake Charlesbus bus
    2. Fly from Lake Charles Regional Airport (LCH) to Lambert–St. Louis International Airport (STL)plane plane LCH - STL
    7h 9m
    $168–671

Lafayette to St. Louis by bus

Calendar7Weekly Buses
Duration18h 45mAverage Duration
Ticket$119Cheapest Price
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Questions & Answers

Map of how to get from Lafayette to St. Louis.ExpandLaunch map view
  • Distance: 613.3 mi
  • Duration: 5h 13m

What companies run services between Lafayette, LA, USA and St. Louis, MO, USA?

United Airlines, Delta, and American Airlines fly from Lafayette Regional Airport (LFT) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Lafayette to St Louis Bus Station via Baton Rouge Bus Station in around 18h 45m.

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