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How to get fromLaguna Niguel to St. Louisby plane, train, bus, train (Amtrak), or car

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There are 7 ways to get from Laguna Niguel to St. Louis by plane, train, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    6h 9m
    $249–919

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Laguna Niguel / Mission Viejo to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    7h 24m
    $150–329

  3. Train, bus

    1. Take the train from Laguna Niguel / Mission Viejo to L.A. Union Stationtrain train OC Line
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    42h 33m
    $300–563

  4. Train via Kansas City

    1. Take the train from San Juan Capistrano Amtrak Station to Fullerton Amtrak Stationtrain train
    2. Take the train from Fullerton Amtrak Station to Kansas Citytrain train
    3. Take the train from Kansas City to St. Louistrain train
    42h 54m
    $648–1,401

  5. Drive 1,817.3 mi

    1. Drive from Laguna Niguel to St. Louiscar car 1,817.3 mi
    29h
    $332–480

  6. Train to San Diego International Airport, fly

    1. Take the train from San Juan Capistrano Amtrak Station to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    7h 15m
    $155–277

  7. Train (Amtrak)

    1. Take the train from San Juan Capistrano Amtrak Station to Los Angelestrain train Pacific Surfliner
    2. Take the train from Los Angeles to St. Louistrain train Texas Eagle
    2d 9h
    $769–1,737

Laguna Niguel to St. Louis by train and bus

Calendar7Weekly Services
Duration42h 33mAverage Duration
Ticket$300Cheapest Price
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Questions & Answers

Map of how to get from Laguna Niguel to St. Louis.ExpandLaunch map view
  • Distance: 1,597.1 mi
  • Duration: 6h 9m

What companies run services between Laguna Niguel, CA, USA and St. Louis, MO, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a train from San Juan Capistrano Amtrak Station to St. Louis via Fullerton Amtrak Station and Kansas City in around 42h 54m.

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