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How to get fromLake City to Jacksonvilleby taxi, bus, train (Amtrak), car, or plane

Find Transport to Jacksonville

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There are 5 ways to get from Lake City to Jacksonville by taxi, bus, train (Amtrak), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus (Flixbus)

    best
    1. Take the taxi from Lake City to Florencetaxi taxi
    2. Take the bus from Florence to Jacksonvillebus bus FlixBus N2472
    6h 23m
    $126–176

  2. Drive 298.4 mi

    cheapest
    1. Drive from Lake City to Jacksonvillecar car 298.4 mi
    4h 57m
    $55–79

  3. Train (Amtrak)

    1. Take the train from Kingstree Station to Jacksonvilletrain train Silver Meteor
    6h 39m
    $144–259

  4. Taxi to Florence Regional Airport, fly

    1. Take the taxi from Lake City to Florence Regional Airport (FLO)taxi taxi
    2. Fly from Florence Regional Airport (FLO) to Jacksonville (JAX)plane plane FLO - JAX
    6h 24m
    $135–461

  5. Drive to Myrtle Beach, fly

    1. Drive from Lake City to Myrtle Beach (MYR)car car
    2. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    6h 12m
    $282–869

Florence Regional Airport (FLO) to Jacksonville (JAX) flights

Calendar13Weekly Planes
Duration4h 32mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Lake City to Jacksonville.ExpandLaunch map view
  • Distance: 343 mi
  • Duration: 6h 23m

What companies run services between Lake City, SC, USA and Jacksonville, FL, USA?

Amtrak operates a train from Kingstree Station to Jacksonville once daily. Tickets cost $95–200 and the journey takes 5h 28m.

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