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How to get fromLake City to Chicagoby bus, plane, bus (Greyhound, Flixbus), train, or car

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There are 6 ways to get from Lake City to Chicago by bus, plane, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Jacksonville, fly to Chicago Midway International Airport

    best
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago Midway International Airport (MDW)plane plane JAX - MDW
    6h 35m
    $108–486

  2. Bus to Valdosta, fly to Chicago Midway International Airport

    cheapest
    1. Take the bus from Lake City Bus Station to Valdostabus bus
    2. Fly from Valdosta (VLD) to Chicago Midway International Airport (MDW)plane plane VLD - MDW
    7h 42m
    $100–431

  3. Bus

    1. Take the bus from Lake City Bus Station to Atlanta Bus Stationbus bus Greyhound US0630
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    22h 50m
    $157–308

  4. Bus, train

    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus Greyhound US0760S
    2. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    38h 8m
    $511–1,121

  5. Drive 956 mi

    1. Drive from Lake City to Chicagocar car 956 mi
    17h 13m
    $175–252

  6. Bus to Jacksonville, fly to Chicago O'Hare International Airport

    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago O'Hare International Airport (ORD)plane plane JAX - ORD
    7h 7m
    $193–526

Lake City to Chicago by bus

Calendar7Weekly Buses
Duration22h 50mAverage Duration
Ticket$157Cheapest Price
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Questions & Answers

Map of how to get from Lake City to Chicago.ExpandLaunch map view
  • Distance: 938.6 mi
  • Duration: 6h 35m

What companies run services between Lake City, FL, USA and Chicago, IL, USA?

You can take a bus from Lake City Bus Station to Chicago Bus Station via Atlanta Bus Station in around 22h 50m.

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