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How to get fromLake City to Key Westby bus, ferry, car, plane, shuttle, or taxi

Find Transport to Key West

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There are 7 ways to get from Lake City to Key West by bus, ferry, car, plane, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, ferry

    best
    1. Take the bus from Lake City to Fort Myersbus bus Houston
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry Fort Myers Beach
    11h 42m
    $256–293

  2. Bus to Jacksonville, fly

    cheapest
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    7h 53m
    $68–322

  3. Drive  516.2 mi

    1. Drive from Lake City to Key Westcar car 516.2 mi
    10h 1m
    $95–137

  4. Drive to Orlando Sanford, fly

    1. Drive from Lake City to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    4h 22m
    $79–333

  5. Bus, shuttle to Tampa, fly

    1. Take the bus from Lake City to Wildwoodbus bus
    2. Take a shuttle bus from Brownwood Hotel & Spa to Tampa International Airport - Red Terminalshuttle bus
    3. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    6h 53m
    $168–410

  6. Bus, taxi to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from Lake City to Ruskinbus bus
    2. Take the taxi from Ruskin to Saint Petersburg–Clearwater International Airport (PIE)taxi taxi
    3. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    6h 36m
    $212–491

  7. Bus, bus to Gainesville Regional Airport, fly

    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Gainesvillebus bus
    3. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    9h 58m
    $79–347

Jacksonville (JAX) to Key West International Airport (EYW) flights

Calendar50Weekly Planes
Duration4h 58mAverage Duration
Ticket$48Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lake City to Key West.ExpandLaunch map view
  • Distance: 479.9 mi
  • Duration: 11h 42m

What companies run services between Lake City, FL, USA and Key West, FL, USA?

There is no direct connection from Lake City to Key West. However, you can take the taxi to Lake City, take the bus to Fort Myers, take the taxi to Fort Myers Beach, FL, then take the ferry to Key West, FL. Alternatively, you can drive from Lake City to Key West in around 10h 1m.

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