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How to get fromLake City to Key Westby bus, plane, ferry, car, or shuttle

Find Transport to Key West

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There are 5 ways to get from Lake City to Key West by bus, plane, ferry, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Jacksonville, fly

    best
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    6h 56m
    $66–301

  2. Bus, ferry

    1. Take the bus from Lake City to Fort Myersbus bus Houston
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry Fort Myers Beach
    11h 42m
    $256–293

  3. Drive  516.2 mi

    1. Drive from Lake City to Key Westcar car 516.2 mi
    10h 1m
    $95–137

  4. Drive to Orlando Sanford, fly

    1. Drive from Lake City to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    4h 22m
    $74–303

  5. Bus, shuttle to Tampa, fly

    1. Take the bus from Lake City to Wildwoodbus bus
    2. Take a shuttle bus from Brownwood Hotel & Spa to Tampa International Airport - Red Terminalshuttle bus
    3. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    6h 52m
    $178–420

Jacksonville (JAX) to Key West International Airport (EYW) flights

Calendar58Weekly Planes
Duration4h 37mAverage Duration
Ticket$44Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lake City to Key West.ExpandLaunch map view
  • Distance: 489.9 mi
  • Duration: 6h 56m

What companies run services between Lake City, FL, USA and Key West, FL, USA?

There is no direct connection from Lake City to Key West. However, you can take the bus to Jacksonville, walk to JRTC Bay J, take the line 1 bus to Jia, walk to Jacksonville (JAX) airport, fly to Key West International Airport (EYW), then take the taxi to Key West. Alternatively, you can take a vehicle from Lake City to Key West, FL via Lake City, Fort Myers, and Fort Myers Beach, FL in around 11h 42m.

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