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How to get fromLake City to Port Saint Lucieby bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Find Transport to Port Saint Lucie

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There are 5 ways to get from Lake City to Port Saint Lucie by bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    3. Take the bus from Orlando to Fort Piercebus bus
    9h 2m
    $63–99

  2. Bus #2 (Greyhound)

    cheapest
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus Greyhound US0760S
    2. Take the bus from Jacksonville to Port St Luciebus bus Greyhound US0710s
    9h 49m
    $44–92

  3. Bus, train

    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Take the train from Jacksonville to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    10h 11m
    $92–172

  4. Drive 269.2 mi

    1. Drive from Lake City to Port Saint Luciecar car 269.2 mi
    4h 22m
    $50–71

  5. Bus via SW Gatlin Blvd & SW Brescia St

    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Port St Luciebus bus
    9h 29m
    $52–92

Lake City to Port Saint Lucie by bus

Calendar14Weekly Buses
Duration9h 2mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from Lake City to Port Saint Lucie.ExpandLaunch map view
  • Distance: 329 mi
  • Duration: 9h 2m

What companies run services between Lake City, FL, USA and Port Saint Lucie, FL, USA?

You can take a bus from Lake City Bus Station to Fort Pierce via Jacksonville, Orlando Bus Station, John Young Pkwy & Amelia St, N Garland Ave & W Amelia St, L B Mcleod Rd & Gardenia Ave, and Orlando in around 9h 2m.

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Bus operators

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Need to know: Greyhound

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