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How to get fromLake City to St. Louisby bus, plane, bus (Greyhound, Flixbus, Amtrak), car, or bus (Greyhound, Flixbus)

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There are 5 ways to get from Lake City to St. Louis by bus, plane, bus (Greyhound, Flixbus, Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Jacksonville, fly

    best
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    6h 27m
    $113–573

  2. Bus via Carbondale

    1. Take the bus from Lake City Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    18h 11m
    $125–234

  3. Drive  838.5 mi

    1. Drive from Lake City to St. Louiscar car 838.5 mi
    13h 53m
    $153–221

  4. Bus to Valdosta, fly

    1. Take the bus from Lake City Bus Station to Valdostabus bus
    2. Fly from Valdosta (VLD) to Lambert–St. Louis International Airport (STL)plane plane VLD - STL
    6h 39m
    $121–588

  5. Bus

    1. Take the bus from Lake City Bus Station to Atlanta Bus Stationbus bus Greyhound US0630
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    18h 30m
    $126–254

Lake City to St. Louis by bus

Calendar5Weekly Buses
Duration18h 11mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Lake City to St. Louis.ExpandLaunch map view
  • Distance: 844.9 mi
  • Duration: 6h 27m

What companies run services between Lake City, FL, USA and St. Louis, MO, USA?

You can take a bus from Lake City Bus Station to St. Louis via Atlanta Bus Station and Carbondale in around 18h 11m.

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