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How to get fromLake City to St. Louisby bus, plane, bus (Greyhound, Flixbus), or car

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There are 7 ways to get from Lake City to St. Louis by bus, plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Jacksonville, fly to Lambert–St. Louis International Airport

    best
    1. Take the bus from Lake City Bus Station to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    6h 21m
    $159–741

  2. Bus

    cheapest
    1. Take the bus from Lake City Bus Station to Atlanta Bus Stationbus bus FlixBus 2451 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    16h 40m
    $133–260

  3. Drive 838.5 mi

    1. Drive from Lake City to St. Louiscar car 838.5 mi
    13h 53m
    $153–221

  4. Bus to Valdosta, fly to Lambert–St. Louis International Airport

    1. Take the bus from Lake City Bus Station to Valdostabus bus
    2. Fly from Valdosta (VLD) to Lambert–St. Louis International Airport (STL)plane plane VLD - STL
    7h 4m
    $142–605

  5. Bus to Gainesville Regional Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Lake City Bus Station to Gainesvillebus bus
    2. Fly from Gainesville Regional Airport (GNV) to Lambert–St. Louis International Airport (STL)plane plane GNV - STL
    8h 12m
    $137–636

  6. Bus to Orlando, fly to Lambert–St. Louis International Airport

    1. Take the bus from Lake City Bus Station to Orlando Bus Stationbus bus
    2. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    8h 59m
    $232–439

  7. Drive to Orlando Sanford, fly to Midamerica St. Louis Airport

    1. Drive from Lake City to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    6h 37m
    $139–482

Lake City to St. Louis by bus

Calendar17Weekly Buses
Duration16h 40mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from Lake City to St. Louis.ExpandLaunch map view
  • Distance: 844.9 mi
  • Duration: 6h 21m

What companies run services between Lake City, FL, USA and St. Louis, MO, USA?

You can take a bus from Lake City Bus Station to St Louis Bus Station via Atlanta Bus Station in around 16h 40m.

Airlines
Bus operators

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