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How to get fromLake Lucerne to Sienaby train (Trenitalia), bus, car, train, or plane

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There are 7 ways to get from Lake Lucerne to Siena by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Flüelen to Chiassotrain train Ic2
    2. Take the train from Chiasso to Milano Centraletrain train S11
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    6h 57m
    €108–310

  2. Train, bus

    cheapest
    1. Take the train from Flüelen to Castione-Arbedotrain train
    2. Take the bus from Bellinzona to Milanbus bus
    3. Take the bus from Milano, Autostazione Lampugnano to Sienabus bus 500 / ...
    10h 20m
    €78–126

  3. Bus

    1. Take the bus from Luzern, Bahnhof to Comobus bus
    2. Take the bus from Como to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    8h 33m

  4. Drive 604.5 km

    1. Drive from Lucerne to Sienacar car 604.5 km
    6h 13m
    €105–151

  5. Train, fly to Florence Peretola Airport

    1. Take the train from Luzern to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 37m
    €120–270

  6. Train via Camorino

    1. Take the train from Flüelen to Cadenazzotrain train
    2. Take the train from Cadenazzo to Milano Centraletrain train
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    8h 31m
    €118–279

  7. Train, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Luzern to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Bologna Guglielmo Marconi Airport (BLQ)plane plane ZRH - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 1m
    €112–275

Lake Lucerne to Siena by train

Calendar6Weekly Trains
Duration6h 57mAverage Duration
Ticket€108Cheapest Price
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Questions & Answers

Map of how to get from Lake Lucerne to Siena.ExpandLaunch map view
  • Distance: 585 km
  • Duration: 6h 57m

What companies run services between Lake Lucerne, Switzerland and Siena, Italy?

You can take a train from Flüelen to Siena via Chiasso, Milano Centrale, and Firenze S.M.N. in around 6h 57m. Alternatively, you can take a bus from Luzern, Bahnhof to Siena via Como, Como Stazione Lago, Como - S. Zenone, Como, and Florence Villa Constanza Bus Station in around 8h 33m.

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