Rome2Rio

How to get fromLake Mary to Greenvilleby plane, taxi, bus (Flixbus, Greyhound), train, bus, car, bus (Flixbus), or bus (Greyhound)

Find Transport to Greenville

See all options

There are 9 ways to get from Lake Mary to Greenville by plane, taxi, bus (Flixbus, Greyhound), train, bus, car, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando Sanford to Asheville Regional Airport, taxi

    best
    1. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    2h 49m
    $208–526

  2. Drive 482.4 mi

    cheapest
    1. Drive from Lake Mary to Greenvillecar car 482.4 mi
    9h 20m
    $88–128

  3. Bus via Atlanta

    1. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    14h 38m
    $133–307

  4. Train, bus

    1. Take the train from Deland to Carytrain train
    2. Take the train from Cary to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    22h 4m
    $289–666

  5. Train to Orlando, fly to Greenville–Spartanburg International Airport

    1. Take the train from Lake Mary to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Greenville–Spartanburg International Airport (GSP)plane plane MCO - GSP
    4h 17m
    $180–751

  6. Fly Orlando Sanford to Greenville–Spartanburg International Airport

    1. Fly from Orlando Sanford (SFB) to Greenville–Spartanburg International Airport (GSP)plane plane SFB - GSP
    1h 58m
    $128–551

  7. Train to Orlando, fly to Asheville Regional Airport, taxi

    1. Take the train from Lake Mary to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Asheville Regional Airport (AVL)plane plane MCO - AVL
    3. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    5h 6m
    $200–486

  8. Bus

    1. Take the bus from Orlando Bus Station to Charlotte Bus Stationbus bus FlixBus 2433
    2. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus Charlotte
    16h 33m
    $142–310

  9. Bus via Gainesville

    1. Take the bus from Orlando Bus Station to Gainesville Bus Stopbus bus
    2. Take the bus from Gainesville Bus Stop to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    18h 29m
    $135–307

Orlando Sanford (SFB) to Asheville Regional Airport (AVL) flights

Calendar11Weekly Planes
Duration1h 39mAverage Duration
Ticket$59Cheapest Price
See schedules

Questions & Answers

Map of how to get from Lake Mary to Greenville.ExpandLaunch map view
  • Distance: 521.4 mi
  • Duration: 2h 49m

What companies run services between Lake Mary, FL, USA and Greenville, SC, USA?

You can take a train from Lake Mary to Greenville via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 14h 38m. Alternatively, Allegiant Air flies from Orlando Sanford (SFB) to Greenville–Spartanburg International Airport (GSP) twice a week.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers