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How to get fromLake Mary to Knoxvilleby plane, train, bus, bus (Flixbus), or car

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There are 7 ways to get from Lake Mary to Knoxville by plane, train, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Orlando Sanford to Mcghee Tyson Airport

    best
    1. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    2h 6m
    $178–736

  2. Fly Orlando Sanford to Asheville Regional Airport, drive

    cheapest
    1. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    3h 59m
    $90–391

  3. Train, bus via Farragut

    1. Take the train from Deland to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York to Knoxvillebus bus Nyc
    36h 10m
    $536–1,007

  4. Bus

    1. Take the bus from Orlando Bus Station to New York City Chinatownbus bus FlixBus N2472
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 39m
    $284–440

  5. Drive 632.5 mi

    1. Drive from Lake Mary to Knoxvillecar car 632.5 mi
    11h 9m
    $116–167

  6. Train to Orlando, fly to Mcghee Tyson Airport

    1. Take the train from Lake Mary to Sand Lake Roadtrain train
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    4h 15m
    $160–676

  7. Train, bus

    1. Take the train from Deland to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 14m
    $491–917

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration1h 38mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Lake Mary to Knoxville.ExpandLaunch map view
  • Distance: 530.4 mi
  • Duration: 2h 6m

What companies run services between Lake Mary, FL, USA and Knoxville, TN, USA?

Allegiant Air flies from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) twice daily. Alternatively, you can take a train from Lake Mary to Knoxville Station Hall of Fame via LYNX Central, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 40h 39m.

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