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How to get fromLakeland to Knoxvilleby car, plane, train, bus, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Lakeland to Knoxville by car, plane, train, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly

    best
    1. Drive from Lakeland to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3h 27m
    $179–740

  2. Drive 645.4 mi

    cheapest
    1. Drive from Lakeland to Knoxvillecar car 645.4 mi
    11h 5m
    $118–171

  3. Train, bus via Farragut

    1. Take the train from Lakeland Amtrak Station to Kissimmee Amtrak Stationtrain train
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    38h 8m
    $567–1,031

  4. Bus via Baltimore

    1. Take the bus from Winter Haven Transportation Center to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Baltimore Downtown Bus Stationbus bus
    3. Take the bus from Baltimore Downtown Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    39h 43m
    $376–584

  5. Train to Orlando, fly

    1. Take the train from Lakeland Amtrak Station to Kissimmee Amtrak Stationtrain train
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    5h 13m
    $173–704

  6. Amtrak Thruway to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from Lakeland to St. Petersburgbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Mcghee Tyson Airport (TYS)plane plane PIE - TYS
    5h 25m
    $188–750

  7. Amtrak Thruway to Sarasota–Bradenton International Airport, fly

    1. Take the bus from Lakeland to Sarasota Amtrak Bus Stopbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Mcghee Tyson Airport (TYS)plane plane SRQ - TYS
    7h 27m
    $241–971

  8. Train, bus

    1. Take the train from Lakeland Amtrak Station to Kissimmee Amtrak Stationtrain train
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    38h 12m
    $522–941

  9. Bus

    1. Take the bus from Winter Haven Transportation Center to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 17m
    $288–450

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration1h 38mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Lakeland to Knoxville.ExpandLaunch map view
  • Distance: 599 mi
  • Duration: 3h 27m

What companies run services between Lakeland, FL, USA and Knoxville, TN, USA?

You can take a bus from Park & Ride at Rose St. to Knoxville via Winter Haven Transportation Center, Orlando Bus Station, Baltimore Downtown Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 39h 43m.

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