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How to get fromLancaster to Buffaloby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, bus, or bus (Flixbus)

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There are 7 ways to get from Lancaster to Buffalo by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Worcester Regional Airport to Buffalo Niagara International Airport

    best
    1. Fly from Worcester Regional Airport (ORH) to Buffalo Niagara International Airport (BUF)plane plane ORH - BUF
    6h 42m
    $155–649

  2. Drive  432.8 mi

    cheapest
    1. Drive from Lancaster to Buffalocar car 432.8 mi
    7h 42m
    $74–107

  3. Train (Amtrak)

    1. Take the train from Worcester Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    12h 11m
    $292–579

  4. Bus

    1. Take the bus from Worcester Union Station to Bostonbus bus Greyhound US0240 / ...
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    13h 8m
    $124–183

  5. Train to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Shirley to North Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 42m
    $143–727

  6. Train to Boston Logan Airport, fly to Rochester, bus

    1. Take the train from Shirley to North Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 59m
    $187–892

  7. Bus via Ithaca

    1. Take the bus from Worcester Union Station to Albany Bus Terminal, NYbus bus
    2. Take the bus from Albany Bus Terminal, NY to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    14h 43m
    $112–239

Worcester Regional Airport (ORH) to Buffalo Niagara International Airport (BUF) flights

Calendar29Weekly Planes
Duration6h 45mAverage Duration
Ticket$92Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lancaster to Buffalo.ExpandLaunch map view
  • Distance: 381.6 mi
  • Duration: 6h 42m

What companies run services between Lancaster, MA, USA and Buffalo, NY, USA?

American Airlines, Delta, and JetBlue Airways fly from Worcester Regional Airport (ORH) to Buffalo Niagara International Airport (BUF) 4 times a day. Alternatively, Amtrak operates a train from Worcester Union Station to Buffalo Depew Station once daily. Tickets cost $240–380 and the journey takes 10h 23m.

Airlines
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