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How to get fromLancaster to Chicagoby bus, plane, bus (Flixbus), train, or car

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There are 6 ways to get from Lancaster to Chicago by bus, plane, bus (Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Chicago Midway International Airport

    best
    1. Take the bus from Lancaster Love's to John Glenn Columbus Intnl Airportbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW)plane plane CMH - MDW
    3h 39m
    $71–435

  2. Bus

    cheapest
    1. Take the bus from Lancaster Love's to N Wilson Rd & Ferrell Pl - Columbusbus bus Route A
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Chicagobus bus Columbus / ...
    9h 12m
    $45–130

  3. Bus via Columbus (Flixbus)

    1. Take the bus from Columbus to Chicago Bus Stationbus bus FlixBus 2511 / ...
    9h 4m
    $85–143

  4. Bus, train

    1. Take the bus from Lancaster Love's to N Wilson Rd & Ferrell Pl - Columbusbus bus
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to Toledo Bus Stopbus bus
    3. Take the train from Toledo to Chicago Union Stationtrain train
    10h 10m
    $109–250

  5. Drive 339.6 mi

    1. Drive from Lancaster to Chicagocar car 339.6 mi
    6h 49m
    $62–90

  6. Bus, fly to Chicago O'Hare International Airport

    1. Take the bus from Lancaster Love's to John Glenn Columbus Intnl Airportbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago O'Hare International Airport (ORD)plane plane CMH - ORD
    4h 2m
    $566–955

John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW) flights

Calendar27Weekly Planes
Duration1h 13mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Lancaster to Chicago.ExpandLaunch map view
  • Distance: 324.2 mi
  • Duration: 3h 39m

What companies run services between Lancaster, OH, USA and Chicago, IL, USA?

Flixbus USA operates a bus from Columbus to Chicago Bus Station twice daily. Tickets cost $55–100 and the journey takes 7h 30m.

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