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How to get fromLancaster to Chicagoby plane, train (Amtrak), bus (Flixbus), car, bus, train, or bus (Greyhound)

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There are 8 ways to get from Lancaster to Chicago by plane, train (Amtrak), bus (Flixbus), car, bus, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lancaster to Chicago O'Hare International Airport

    best
    1. Fly from Lancaster (LNS) to Chicago O'Hare International Airport (ORD)plane plane LNS - ORD
    4h 46m
    $59–300

  2. Train via Pittsburgh (Amtrak)

    1. Take the train from Elizabethtown Amtrak Station to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    18h 45m
    $235–491

  3. Bus

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    19h 49m
    $126–221

  4. Drive 691.6 mi

    1. Drive from Lancaster to Chicagocar car 691.6 mi
    11h 24m
    $127–183

  5. Line 18 bus to Harrisburg International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Queen St. Station to AMTRAK ETownbus bus
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    7h 17m

  6. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    7h 49m
    $173–463

  7. Bus via Baltimore

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    24h 44m
    $138–265

  8. Train (Amtrak)

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train Keystone Service / ...
    2. Take the train from 30th Street Station to Chicago Union Stationtrain train Cardinal
    31h 37m
    $368–755

Lancaster to Chicago by bus and train (Amtrak)

Calendar7Weekly Services
Duration18h 45mAverage Duration
Ticket$235Cheapest Price
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Questions & Answers

Map of how to get from Lancaster to Chicago.ExpandLaunch map view
  • Distance: 641.8 mi
  • Duration: 4h 46m

What companies run services between Lancaster, PA, USA and Chicago, IL, USA?

United Airlines flies from Lancaster (LNS) to Chicago O'Hare International Airport (ORD) twice daily. Alternatively, you can take a bus from W. Walnut & N. Mary St. to Chicago Union Station via AMTRAK ETown, Elizabethtown Amtrak Station, and Pittsburgh Amtrak Station in around 18h 45m.

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