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How to get fromLancaster to Durhamby bus (Greyhound, Flixbus), train (Amtrak), car, bus, train, or plane

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There are 8 ways to get from Lancaster to Durham by bus (Greyhound, Flixbus), train (Amtrak), car, bus, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington Union Station to Durhambus bus FlixBus N2471 / ...
    12h 44m
    $74–129

  2. Drive  360.3 mi

    cheapest
    1. Drive from Lancaster to Durhamcar car 360.3 mi
    6h 56m
    $62–89

  3. Train (Amtrak)

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Durham Amtrak Stationtrain train
    13h 31m
    $257–1,012

  4. Line 18 bus, train to Harrisburg International Airport, fly to Raleigh-Durham International Airport, line 700 bus

    1. Take the bus from Queen St. Station to AMTRAK ETownbus bus
    2. Take the train from Elizabethtown Amtrak Station to Harrisburgtrain train
    3. Fly from Harrisburg International Airport (MDT) to Raleigh-Durham International Airport (RDU)plane plane MDT - RDU
    4. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    9h 11m

  5. Line 18 bus, train to Philadelphia International Airport, fly to Raleigh-Durham International Airport, line 700 bus

    1. Take the bus from Queen St. Station to AMTRAK ETownbus bus
    2. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Raleigh-Durham International Airport (RDU)plane plane PHL - RDU
    4. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    8h 5m

  6. Train to Philadelphia International Airport, fly to Piedmont Triad International Airport, train

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Piedmont Triad International Airport (GSO)plane plane PHL - GSO
    3. Take the train from Greensboro to Durham Amtrak Stationtrain train
    9h 5m
    $198–761

  7. Train, train to Baltimore-Washington International Airport, fly to Raleigh-Durham International Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Raleigh-Durham International Airport (RDU)plane plane BWI - RDU
    9h 5m
    $162–1,328

  8. Train, train to Ronald Reagan Washington National Airport, fly to Raleigh-Durham International Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Raleigh-Durham International Airport (RDU)plane plane DCA - RDU
    9h 50m
    $182–1,435

Lancaster to Durham by bus and train

Calendar4Weekly Services
Duration12h 44mAverage Duration
Ticket$74Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lancaster to Durham.ExpandLaunch map view
  • Distance: 438.9 mi
  • Duration: 12h 44m

What companies run services between Lancaster, PA, USA and Durham, NC, USA?

You can take a bus from Queen St. Station to Durham via AMTRAK ETown, Elizabethtown Amtrak Station, Harrisburg, Harrisburg Bus Station, and Washington Union Station in around 12h 44m. Alternatively, you can take a bus from W. Walnut & N. Mary St. to Durham Amtrak Station via AMTRAK ETown, Elizabethtown Amtrak Station, 30th Street Station, and Washington Union Station in around 13h 31m.

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