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How to get fromLancaster to Florenceby bus (Greyhound, Flixbus), train (Amtrak), car, plane, bus, or train

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There are 7 ways to get from Lancaster to Florence by bus (Greyhound, Flixbus), train (Amtrak), car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    15h 52m
    $84–164

  2. Train (Amtrak)

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train Keystone Service / ...
    2. Take the train from 30th Street Station to Florence Stationtrain train Palmetto / ...
    17h 36m
    $197–416

  3. Drive 503.8 mi

    1. Drive from Lancaster to Florencecar car 503.8 mi
    9h 16m
    $92–133

  4. Fly Harrisburg International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Harrisburg International Airport (MDT) to Charlotte Douglas International Airport (CLT)plane plane MDT - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    11h 25m
    $198–1,156

  5. Bus, train

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    3. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    16h 40m
    $98–191

  6. Fly Harrisburg International Airport to Myrtle Beach, bus, train

    1. Fly from Harrisburg International Airport (MDT) to Myrtle Beach (MYR)plane plane MDT - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h 58m
    $161–771

  7. Train to Philadelphia International Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Myrtle Beach (MYR)plane plane PHL - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    12h 56m
    $155–587

Lancaster to Florence by bus and train

Calendar14Weekly Services
Duration15h 52mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from Lancaster to Florence.ExpandLaunch map view
  • Distance: 566 mi
  • Duration: 15h 52m

What companies run services between Lancaster, PA, USA and Florence, SC, USA?

You can take a bus from Queen St. Station to Florence Bus Station via AMTRAK ETown, Elizabethtown Amtrak Station, Harrisburg, Harrisburg Bus Station, Baltimore Downtown Bus Station, and Raleigh Bus Station in around 15h 52m. Alternatively, you can take a bus from W. Walnut & N. Mary St. to Florence Station via AMTRAK ETown, Elizabethtown Amtrak Station, and 30th Street Station in around 17h 36m.

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